EMT

[Cancer Gene Therapy] Investigators examined the expression of all centromere proteins and their association with recurrence and survival of hepatocellular carcinoma patients using the global gene expression profile dataset established in our laboratory.

[Developmental Cell] Researchers employed tamoxifen-inducible dual recombinase lineage tracing systems combined with live imaging and 5-cell RNA sequencing to track cancer cells undergoing partial or full epithelial-mesenchymal transition (EMT) in the MMTV-PyMT mouse model of metastatic breast cancer.

[Cell Death & Disease] Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes.

[Bioengineered] Researchers found high TSPAN1 expression in breast cancer tumor samples and cell lines which was confirmed by bioinformation analysis. The ablation of TSPAN1 suppressed the growth, and motility of breast cancer cells and affected the epithelial-mesenchymal transition in breast cancer cells.

[Cell Death & Disease] Researchers probed the function and potential mechanism of KCNK15-AS1 in pancreatic cancer (PC) cell growth. RT-qPCR and western blot were employed to measure gene expression in PC cells.

[BMC Cancer] Researchers hypothesized that IL8 might regulate migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells through the ERK pathway.