EMT

[Circulation] Genetic fate mapping results revealed that a subset of cardiac endothelial cells transiently expressed αSMA and Zeb1 during embryonic valve formation and transdifferentiated into mesenchymal cells through EndoMT.

[Scientific Reports] Scientists demonstrated for the first time that TGF-β could elicit epithelial–mesenchymal transition in a mouse lung adenocarcinoma cell line.

[Oncogenesis] Researchers studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dynamics of HER2 status. A dynamic model of HER2 status could lead to the identification of new druggable targets to counteract the resistance to HER2-targeted therapy caused by HER2 loss.

[Cancers] Researchers showed that inhibition of RAC1 activation attenuated pluripotency marker expression and self-renewal ability, while depletion of RAC1b dramatically enhanced stemness features and clonogenic potential.

[Laboratory Investigation] Researchers suggested that angiogenesis promoted beta-cell survival in the inflamed pancreas, while suppression of angiogenesis turned beta-cell epithelial–mesenchymal transition into apoptotic beta-cell death.

[Scientific Reports] The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.