EMT

[BMC Research Notes] Scientists evaluated whether placental extract influences epithelial–mesenchymal transition (EMT) and fibrosis through cytokine-induced EMT in the retinal pigment epithelial cells, in vitro.

[International Journal of Cancer] Investigators applied droplet-based single-cell RNA sequencing (scRNA-seq) to acquire transcriptional profiles of 36 619 single cells isolated from seven patients.

[Cell Death & Disease] The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.

[Neoplasia] Scientists discovered that brain-type creatine kinase (CKB) was a negative regulator of epithelial-mesenchymal transition and AKT activation, which revealed a new mode of their regulation.

[Cell Death & Disease] Investigators found that circPRKAR1B enhanced osteosarcoma (OS) cell proliferation, migration, and promoted OS epithelial–mesenchymal transition.

[Cell Death & Disease] In vitro functional investigations revealed that the interaction between AnnexinA7 and Sorcin regulated epithelial–mesenchymal transition, and then affected migration, invasion, and proliferation in hepatocellular carcinoma cells.