EMT

[Science Advances] Researchers showed that GLIS2 inactivation promoted mammary stem cell stemness, and GLIS2 is required for normal mammary gland development, while GLIS2 inactivation induced the proliferative and tumorigenic capacities of the mammary tumor–initiating cells of claudin-low breast cancers.

[Cell Death & Disease] The authors used a murine model of orthotopic breast cancer to study the tumor-intrinsic role of cyclin-dependent kinase 8 (CDK8) in TNBC and linked CDK8 to programmed death-ligand 1 expression.

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Journal of Nanobiotechnology] Researchers reported a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu (177Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor.

[Experimental & Molecular Medicine] Correlations of KLF10 deficiency with rapid metastasis, elevated EMT, and glycolysis were demonstrated in resected pancreatic adenocarcinoma tissues, in vitro assays, and murine models.

[Human Cell] Researchers elucidated the role of histone deacetylase 6 in regulating epithelial-mesenchymal transition-mediated metastasis via mRNA in NSCLC.