Upregulating Sirtuin 6 Ameliorates Glycolysis, EMT and Distant Metastasis of Pancreatic Adenocarcinoma with Krüppel-Like Factor 10 Deficiency

Correlations of KLF10 deficiency with rapid metastasis, elevated EMT, and glycolysis were demonstrated in resected pancreatic adenocarcinoma tissues, in vitro assays, and murine models.