Infectious Disease in an Era of Global Change

The authors consider the extent to which recent global changes have increased the risk of infectious disease outbreaks, even as improved sanitation and access to health care have resulted in considerable progress worldwide.
[Nature Reviews Microbiology]
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SERINC Proteins Potentiate Antiviral Type I IFN Production and Proinflammatory Signaling Pathways

Scientists found that SERINC3 and SERINC5 exhibited additional antiviral activities by enhancing the expression of genes encoding type I interferons and nuclear factor κB signaling.
[Science Signaling]
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Neutralizing Monoclonal Antibodies for Treatment of COVID-19

The authors review the precedent for passive immunization and lessons learned from using antibody therapies for viral infections such as respiratory syncytial virus, Ebola virus and SARS-CoV infections.
[Nature Reviews Immunology]
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Cellular mRNA Triggers Structural Transformation of Ebola Virus Matrix Protein VP40 to Its Essential Regulatory Form

Researchers showed that suitable nucleic acid is sufficient to trigger a dynamic transformation of VP40 dimer into the octameric ring.
[Cell Reports]
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A Fc Engineering Approach to Define Functional Humoral Correlates of Immunity against Ebola Virus

The authors generated a library of Fc variants with identical antigen-binding fragments from an Ebola virus neutralizing antibody.
[Immunity]
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The Shape of Pleomorphic Virions Determines Resistance to Cell-Entry Pressure

Scientists suggest that therapeutics targeting filamentous virus particles could overcome antiviral drug resistance and immune evasion in pleomorphic viruses.
[Nature Microbiology]
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Biological Activity-Based Modeling Identifies Antiviral Leads against SARS-CoV-2

Scientists report a biological activity-based modeling approach, in which compound activity profiles established across multiple assays were used as signatures to predict compound activity in other assays or against a new target.
[Nature Biotechnology]
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Ebola Virus Antibody Decay–Stimulation in a High Proportion of Survivors

Using a robust in vitro Ebola virus pseudo-particle infection assay and a well-defined set of solid-phase assays, scientists describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Sierra Leone EBOV outbreak of 2013–2016.
[Nature]
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Structural Insights Into RNA Polymerases of Negative-Sense RNA Viruses

The authors compare recent high-resolution X-ray and cryoelectron microscopy structures of RNA polymerases of negative-sense RNA viruses with segmented and non-segmented genomes.
[Nature Reviews Microbiology]
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Transcriptomic Similarities and Differences in Host Response between SARS-CoV-2 and Other Viral Infections

Researchers studied the whole-blood transcriptomic host response to SARS-CoV-2 using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19.
[iScience]
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Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

The authors used single-cell transcriptomics and CyTOF-based single-cell protein quantification to characterize peripheral immune cells during EBOV infection in rhesus monkeys.
[Cell]
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