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Ebola Virus Persistence and Disease Recrudescence in the Brains of Antibody-Treated Nonhuman Primate Survivors

[Science Translational Medicine] In monoclonal antibody-treated macaque survivors, Ebola virus disease persisted in macrophages infiltrating the brain ventricular system, including the choroid plexuses.

Recombinant Lloviu Virus as a Tool to Study Viral Replication and Host Responses

[PLoS Pathogens] Similar to other filoviruses, recombinant Lloviu virus formed filamentous virions and induced the formation of characteristic inclusions in the cytoplasm of the infected cells, as shown by electron microscopy.

Rapid Protection from COVID-19 in Nonhuman Primates Vaccinated Intramuscularly but Not Intranasally with a Single Dose of a Vesicular Stomatitis Virus-Based Vaccine

[mBio] Researchers generated a single-dose, fast-acting vesicular stomatitis virus (VSV)-based vaccine derived from the licensed Ebola virus (EBOV) vaccine rVSV-ZEBOV, expressing the SARS-CoV-2 spike protein and the EBOV glycoprotein.

A Virus-Specific Monocyte Inflammatory Phenotype Is Induced by SARS-CoV-2 at the Immune–Epithelial Interface

[Proceedings of the National Academy of Sciences of the United States of America] A strong response was induced in monocytes and B cells, with a SARS-CoV-2–specific inflammatory gene cluster distinct from that seen in influenza A or Ebola virus-infected cocultures, and which reproduced deviations reported in blood or lung myeloid cells from COVID-19 patients.

Infectious Disease in an Era of Global Change

[Nature Reviews Microbiology] The authors consider the extent to which recent global changes have increased the risk of infectious disease outbreaks, even as improved sanitation and access to health care have resulted in considerable progress worldwide.

SERINC Proteins Potentiate Antiviral Type I IFN Production and Proinflammatory Signaling Pathways

[Science Signaling] Scientists found that SERINC3 and SERINC5 exhibited additional antiviral activities by enhancing the expression of genes encoding type I interferons and nuclear factor κB signaling.