H3K27

[Scientific Reports] Scientists investigated the relationship between the expression of EZH1/2 and the level of histone H3 Lysine 27 trimethylation in hepatocellular carcinoma.

[Cancer Research] Scientists reported that specific homozygous deletion of KDM6A in the adult mouse prostate epithelium strongly inhibited tumor progression initiated by the homozygous loss of PTEN. Mechanistically, KDM6A promoted prostate tumorigenesis and lipid metabolism by binding to the SREBP1c promoter which resulted in increased SREBP1c transcription.

[Blood] Scientists reported that CUX1 had a critical early role in the DNA repair process in hematopoietic stem and progenitor cells. Mechanistically, CUX1 recruited the histone methyltransferase EHMT2 to DNA breaks to promote downstream H3K9 and H3K27 methylation, phosphorylated ATM retention, subsequent γH2AX focus formation and propagation, and, ultimately, 53BP1 recruitment.

[Science Advances] Scientists reported the successful generation of trophoblast stem cells (TSCs) from primed human PSCs (hPSCs) and showed that BMP4 substantially enhanced this process. TSCs derived from primed hPSCs were similar to blastocyst-derived human TSCs in terms of morphology, proliferation, differentiation potential, and gene expression.

[Cell Death & Disease] Scientists investigated the regulation of histone deacetylase 2 (HDAC2) on the interferon gamma-induced PD-L1 expression in TNBC cells and found the HDAC2 and PD-L1 expression in TNBC was significantly higher than that in non-TNBC, and HDAC2 was positively correlated with PD-L1 expression.

[Oncogene] Scientists review how canonical functions of Enhancer of Zeste Homolog 2 as a histone methyltransferase activity are regulated and describe the various mechanisms of Polycomb Repressive Complex 2 recruitment to the chromatin.