Efficient Derivation of Human Trophoblast Stem Cells from Primed Pluripotent Stem Cells

Scientists reported the successful generation of trophoblast stem cells (TSCs) from primed human PSCs (hPSCs) and showed that BMP4 substantially enhanced this process. TSCs derived from primed hPSCs were similar to blastocyst-derived human TSCs in terms of morphology, proliferation, differentiation potential, and gene expression.