HIV

[Science Immunology] Investigators found that monophosphoryl lipid A (MPLA) self-assembled with saponins to form particles physically resembling immune-stimulatory complexes, which they termed saponin/MPLA nanoparticles.

[BeiGene, Ltd. (BusinessWire, Inc.)] BeiGene, Ltd. and EUSA Pharma, Ltd. announced that the China National Medical Products Administration has approved SYLVANT® for the treatment of adult patients with multicentric Castleman disease who are HIV negative and human herpes virus-8 negative,.

[PLoS Pathogens] Investigators compared vaccine responses in Phase I and II studies in humans utilizing various combinations of DNA/vector, vector/vector and DNA/protein HIV vaccines.

[mBio] Investigators used RNA sequencing to determine that HIV-1 alone induced few or no signs of an type I interferon response in THP-1 cells.

[Proceedings of the National Academy of Sciences of the United States of America] The authors reported that RORC2 was a key host cofactor for HIV replication in Th17 cells. They found that specific inhibitors that bound to the RORC2 ligand-binding domain reduced HIV replication in CD4+ T cells.

[Nature Reviews Immunology] Scientists discuss novel latency-reversing agents targeting DCs as well as DC-based strategies to enhance the clearance of infected cells by CD8+ T cells and strategies to improve the killing activity of natural killer cells.