HTT

[Nature Neuroscience] Mutating endogenous FAN1 to a nuclease-inactive form in an induced pluripotent stem cell model of Huntington’s diseas led to rates of CAG expansion similar to those observed with complete FAN1 knockout.

[NPJ Regenerative Medicine] Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.

[Stem Cell Research & Therapy] The authors observed if transplantation of superparamagnetic iron oxide nanoparticle-labeled human ESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model.

[Cell Reports] The authors investigated mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in glial pathobiology across species and models.

[Scientific Reports] Scientists aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that expression of mutant Htt decreased the synaptic output of striatal neurons in a cell autonomous fashion and identified a number of genes whose dysregulation was correlated with physiological deficiencies in mutant Htt neurons.