NewslettersESC & iPSC NewsUncategorizedExome Sequencing of Individuals with Huntington’s Disease Implicates FAN1 Nuclease Activity in Slowing CAG Expansion and Disease OnsetBy Justin.choi - April 6, 2022035Mutating endogenous FAN1 to a nuclease-inactive form in an induced pluripotent stem cell model of Huntington’s diseas led to rates of CAG expansion similar to those observed with complete FAN1 knockout.[Nature Neuroscience] 6445212 AAAAAAAA items 1 apa 0 default asc 1 173712 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/Full Article