The authors showed elevated activation of the MTOR pathway in human-derived astrocytes harboring mutant SOD1, which resulted in inhibition of macroautophagy/autophagy, increased cell proliferation, and enhanced astrocyte reactivity.
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The authors explored the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of prostate cancer cells.
[Prostate Cancer and Prostatic Diseases]
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The authors identified an inhibitor of insulin receptor and IGF1 receptor signaling in mouse β-cells, which they named the insulin inhibitory receptor.
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Scientists showed that PKCδ is a secretory protein that regulated cell growth of liver cancer. Full-length PKCδ was secreted to the extracellular space in living liver cancer cells under normal cell culture conditions and in xenograft mouse models.
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Yamada, K., Oikawa, T., Kizawa, R., Motohashi, S., Yoshida, S., Kumamoto, T., Saeki, C., Nakagawa, C., Shimoyama, Y., Aoki, K., Tachibana, T., Saruta, M., Ono, M., & Yoshida, K. (2020). Unconventional secretion of PKCδ exerts tumorigenic function via stimulation of ERK1/2 signaling in liver cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2009 Cite
The transcriptomes of primary tumors and metastases in mice harbouring estrogen receptor+ breast cancer patient-derived xenografts were analysed following single-cell RNAseq. In vitro assays were employed to delineate mechanisms of endocrine resistance and stemness.
[British Journal of Cancer]
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Dwyer, A. R., Truong, T. H., Kerkvliet, C. P., Paul, K. V., Kabos, P., Sartorius, C. A., & Lange, C. A. (2020). Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-020-01094-y Cite
The authors identified KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled RNAi screen and confirmed the finding by using a genetically engineered mouse model based on conditional and melanocyte-specific deletion of KMT2D.
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Maitituoheti, M., Keung, E. Z., Tang, M., Yan, L., Alam, H., Han, G., Singh, A. K., Raman, A. T., Terranova, C., Sarkar, S., Orouji, E., Amin, S. B., Sharma, S., Williams, M., Samant, N. S., Dhamdhere, M., Zheng, N., Shah, T., Shah, A., … Rai, K. (2020). Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108293 Cite
Researchers interrogated N6-methyladenosine (m6A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.
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Dixit, D., Prager, B. C., Gimple, R. C., Poh, H. X., Wang, Y., Wu, Q., Qiu, Z., Kidwell, R. L., Kim, L. J. Y., Xie, Q., Vitting-Seerup, K., Bhargava, S., Dong, Z., Jiang, L., Zhu, Z., Hamerlik, P., Jaffrey, S. R., Zhao, J. C., Wang, X., & Rich, J. N. (2020). The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0331 Cite
Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
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The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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