IGF1R

[Cell Reports] By conditional knockout in mammary stem cells, investigators demonstrated that protein C receptor (Procr) is essential for mammary gland development and homeostasis.

[Cell Research] The authors demonstrated that Lepr+ MSCs surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.

[Laboratory Investigation] Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B-cell lymphoma.

[Cell Biology International] Researchers suggested that upregulation of miR-122 induced apoptosis, potentially via the repression of insulin-like growth factor 1 receptor (IGF1R) in human dermal papilla cells of androgenetic alopecia.

[Cancer Cell International] The authors identified novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.

[Advanced Science] A low-cost protocol for cardiomyocyte differentiation from mouse ESCs is presented and it is shown that Pten deletion potently suppressed cardiomyocyte differentiation.