IGF1R

[Molecular Medicine Reports] M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.

[Science Signaling] Scientists used a temporally restricted model of hepatic repair in which large-scale hepatocyte injury and regeneration were initiated through the acute loss of Mdm2 in hepatocytes, resulting in the rapid, coordinated proliferation of biliary epithelial cells.

[Prostate Cancer and Prostatic Diseases] The authors explored the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of prostate cancer cells.

[Autophagy] The authors showed elevated activation of the MTOR pathway in human-derived astrocytes harboring mutant SOD1, which resulted in inhibition of macroautophagy/autophagy, increased cell proliferation, and enhanced astrocyte reactivity.

[Nature] The authors identified an inhibitor of insulin receptor and IGF1 receptor signaling in mouse β-cells, which they named the insulin inhibitory receptor.

[Cancer Research] Scientists showed that PKCδ is a secretory protein that regulated cell growth of liver cancer. Full-length PKCδ was secreted to the extracellular space in living liver cancer cells under normal cell culture conditions and in xenograft mouse models.