Modulation of the IGF1R-MTOR Pathway Attenuates Motor Neuron Toxicity of Human ALS SOD1G93A Astrocytes

By
Justin.choi
-
0
35
The authors showed elevated activation of the MTOR pathway in human-derived astrocytes harboring mutant SOD1, which resulted in inhibition of macroautophagy/autophagy, increased cell proliferation, and enhanced astrocyte reactivity.
[Autophagy]
Granatiero, V., Sayles, N. M., Savino, A. M., Konrad, C., Kharas, M. G., Kawamata, H., & Manfredi, G. (2021). Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes. Autophagy, 0(0), 1–14. https://doi.org/10.1080/15548627.2021.1899682 Cite
Abstract