IL-23

[International Immunopharmacology] Scientists modified the classical antigen-induced arthritis model by using citrullinated human plasma fibrinogen as an immunogen to investigate the mechanism of inflammation-driven joint damage by citrullinated human plasma fibrinogen (hFIB) in C57BL/6 mice.

[Science Immunology] Researchers showed that mice having a keratinocyte-specific deletion of Fn14, the receptor for the tumor necrosis factor (TNF) superfamily cytokine TWEAK, displayed reduced imiquimod-induced skin inflammation, diminished epidermal hyperplasia and less expression of psoriasis signature genes.

[Cell Death & Disease] The authors investigated a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production.

[Cell Reports] The authors demonstrated a trigger of thymic regeneration, centered on detecting the loss of dying thymocytes that were abundant during steady-state T cell development.

[AbbVie, Inc.] AbbVie announced that it has submitted an application to the US FDA seeking approval for risankizumab-rzaa, an interleukin-23 inhibitor, for the treatment of patients 16 years and older with moderate to severe Crohn's disease.

[Scientific Reports] Scientists investigated the effect of 2ʹ(3ʹ)-O-(4-benzoyl benzoyl) ATP (BzATP) on the production of inflammatory cytokines in both monocyte-generated and M1 macrophages from patients and controls.