IL-23

[International Journal of Molecular Sciences] Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.

[Blood] Investigators used conventional and novel sequential immunostaining and flow cytometry to scrutinize RA-responsive T-cells in tissues and blood of allogeneic hematopoietic stem-cell transplantation patients and characterized the impact of RA on human T-cell alloresponses.

[Experimental and Molecular Medicine] The authors found that the Pellino ubiquitin E3 ligase is activated by innate pattern-recognition receptors, such as Toll-like receptors, and was highly upregulated in human psoriatic skin lesions and murine psoriasis-like models.

[Scientific Reports] Investigators report here that IL-17A mRNA and protein were detectable in some human triple-negative breast cancer cell lines and further upregulated by IL-23 and LPS stimulation.

[Mucosal Immunology] Investigators characterized a population of interleukin 17-producing γδ T cells that seeded the testis of naive C57BL/6 mice, expand at puberty and persisted throughout adulthood.