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IL-6

Human Induced Pluripotent Stem Cell-Derived Macrophages Ameliorate Liver Fibrosis

[Stem Cells] Investigators demonstrated that treatment of liver fibrosis with both human induced pluripotent stem cell-derived macrophage populations and especially M2 subtype significantly reduced fibrogenic gene expression and disease associated histological markers in immunodeficient Rag2−/−γc−/− mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.

AEG-1 Silencing Attenuates M2-Polarization of Glioma-Associated Microglia/Macrophages and Sensitizes Glioma Cells to Temozolomide

[Scientific Reports] Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.

Redundant Cytokine Requirement for Intestinal Microbiota-Induced Th17 Cell Differentiation in Draining Lymph Nodes

[Cell Reports] Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.

Amygdalin Attenuates Airway Epithelium Apoptosis, Inflammation, and Epithelial-Mesenchymal Transition through Restraining the TLR4/NF-κB Signaling Pathway on LPS-Treated BEAS-2B Bronchial Epithelial Cells

[International Archives of Allergy and Immunology] Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.

Particulate Matter-Induced Atmospheric Skin Aging Is Aggravated by UVA and Inhibited by a Topical L-Ascorbic Acid Compound

[Photodermatology Photoimmunology & Photomedicine] Scientists analyzed whether ultraviolet A aggravated the particulate matter-induced inflammatory cascade, which contributed to the aging of skin-derived cells.

E-Cigarette Fluids and Aerosol Residues Cause Oxidative Stress and an Inflammatory Response in Human Keratinocytes and 3D Skin Models

[Toxicology in Vitro] Investigators evaluated the effects of electronic cigarette (EC) refill fluids and EC exhaled aerosol residue on cultured human keratinocytes and MatTek EpiDerm™, a 3D air liquid interface human skin model.

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