Human Induced Pluripotent Stem Cell-Derived Macrophages Ameliorate Liver Fibrosis

Investigators demonstrated that treatment of liver fibrosis with both human induced pluripotent stem cell-derived macrophage populations and especially M2 subtype significantly reduced fibrogenic gene expression and disease associated histological markers in immunodeficient Rag2−/−γc−/− mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.