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IL-6

The Circular RNA circNlgn Mediates Doxorubicin-Induced Cardiac Remodeling and Fibrosis

[Molecular Therapy-Nucleic Acids] Scientists developed a transgenic mouse line overexpressing the circular RNA circNlgn and showed that circNlgn was a mediator of Doxorubicin-induced cardio-fibrosis.

Bordetella pertussis-Infected Innate Immune Cells Drive the Anti-pertussis Response of Human Airway Epithelium

[Scientific Reports] Researchers investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium differentiated at air–liquid interface.

Knockdown of Circ_0001679 Alleviates Lipopolysaccharide-Induced MLE-12 Lung Cell Injury by Regulating the miR-338-3p/ Mitogen-Activated Protein Kinase 1 Axis

[Bioengineered] Researchers indicated that circ_0001679/miR-338-3p/MAPK1 axis may play an important role in the pathogenesis of acute lung injury.

Tocilizumab Overcomes Chemotherapy Resistance in Mesenchymal Stem-Like Breast Cancer by Negating Autocrine IL-1A Induction of IL-6

[npj Breast Cancer] In order to gain insight into pathways that contributed to the divergent sensitivity to chemotherapy, scientists compared the inflammatory profile of the TNBC subtypes treated with docetaxel.

Astragalus and Human Mesenchymal Stem Cells Promote Wound Healing by Mediating Immunomodulatory Effects through Paracrine Signaling

[Regenerative Medicine] A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of MSCs. CD11b+ and CD45 macrophages were detected and levels of cytokines were tested.

S1P Analogues SEW2871, BAF312 and FTY720 Affect Human Th17 and Treg Generation Ex Vivo

[International Immunopharmacology] The authors investigated the effects of S1P receptor 1 (S1P1) specific S1P analogue SEW2871, S1P1 and S1P5 specific BAF312, and non-selective FTY720 on human Th17 and Treg differentiation and IL-23-mediated signaling.

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