IL-8

[Arthritis & Rheumatology] Antiphospholipid autoantibodies increased human endometrial stromal cell decidualization, senescence and inflammation. The decidualization and inflammatory responses were partially mediated by toll-like receptor 4 (TLR4) and p38 MAP kinase, while the decidualization and senescence responses were reactive oxygen species (ROS)-dependent.

[Inflammation] Researchers evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A.

[Inflammation] The authors evaluated the effects of the association between Cryptococcus neoformans and Dermatophagoides pteronyssinus in the modulation of airway inflammatory responses in an in vitro experimental model using human bronchial epithelial cells.

[Acta Biomaterialia] Scientists assessed the effects of sodium alginate microencapsulation on human MSC secretion of immunomodulatory cytokines in an osteoarthritis (OA) microenvironment and therapeutic efficacy in treating established OA.

[Molecular Oncology] Scientists found that both Sirtuin 1 (SIRT1) and SIRT1 phosphorylated on serine 27 were coordinately upregulated in colon cancer patients’ tissues and human colon cancer cell lines.

[Toxicology in Vitro] Researchers studied IL-8 secretion, as a marker of pro-inflammatory response through the Toll-like receptor (TLR) pathway, in a Caco-2 monoculture, Caco-2/HT29-MTX di-culture, Caco-2/HT29-MTX/HMVEC-d tri-culture and in a HT29-p monoculture in response to exposure to various TLR agonists.