Scientists showed that ablation of tuberous sclerosis complex 2, a negative regulator of mammalian target of rapamycin complex 1 (mTORC1), specifically in intestinal epithelial cells of mice resulted in increased activity of mTORC1 of, as well as increased proliferative activity of, colonic epithelial cells.
1254621 IVVACRTI items 1 apa default asc 1
Investigators evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which was a cancer stem cell marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally.
6606345 4ULC45HY items 1 apa default asc 1
The authors demonstrate that the DNA damage-resistant Msi1+ cells are cycling intestinal stem cells that maintain and regenerate the intestinal epithelium.
6606345 S5YLMWFM items 1 apa default asc 1
The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
[Cell Stem Cell]
1254621 A6J5HKZR items 1 apa default asc 1