Regulation of Colonic Epithelial Cell Homeostasis by mTORC1

Scientists showed that ablation of tuberous sclerosis complex 2, a negative regulator of mammalian target of rapamycin complex 1 (mTORC1), specifically in intestinal epithelial cells of mice resulted in increased activity of mTORC1 of, as well as increased proliferative activity of, colonic epithelial cells.
[Scientific Reports]
Kotani, T., Setiawan, J., Konno, T., Ihara, N., Okamoto, S., Saito, Y., Murata, Y., Noda, T., & Matozaki, T. (2020). Regulation of colonic epithelial cell homeostasis by mTORC1. Scientific Reports, 10(1), 13810. https://doi.org/10.1038/s41598-020-70655-1 Cite
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Continuous Formation of Small Clusters with LGR5-Positive Cells Contributes to Tumor Growth in a Colorectal Cancer Xenograft Model

Investigators evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which was a cancer stem cell marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally.
[Laboratory Investigation]
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Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

The authors demonstrate that the DNA damage-resistant Msi1+ cells are cycling intestinal stem cells that maintain and regenerate the intestinal epithelium.
[Cell Reports]
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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
[Cell Stem Cell]
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