Lgr5

[Nature] Using a non-human primate model of lung injury, together with human organoids and tissue specimens, researchers showed that alveolar type-2 cells in regenerating lungs transiently acquire an alveolar type-0 state from which they can differentiate into either alveolar type-1 cells or respiratory bronchiole-secretory cells.

[Molecular Nutrition & Food Research] Intestinal organoids and mice were used to explore the effects of milk-derived small extracellular vesicles on intestinal regeneration.

[JCI Insight] While azoxymethane delivery in vivo under non-adenoma-forming conditions yielded phenotypically normal mucosa and organoids derived thereof, niche injury ex vivo by progressive dextran sulfate sodium dose escalation facilitated outgrowth of Wnt-independent dysplastic organoids.

[Small] The authors found that gelatin methacryloyl (GelMA)-nanoclay hybrid hydrogels could induce and enrich colorectal cancer stem cells assisted by three-dimensional bioprinting.

[Nature Communications] Scientists showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.

[Immunity] The authors used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut.