Silencing PTEN in the Fallopian Tube Promotes Enrichment of Cancer Stem Cell-Like Function through Loss of PAX2

Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
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Suppression of Elevated Cdc42 Activity Promotes the Regenerative Potential of Aged Intestinal Stem Cells

Elevation of Cdc42 activity in young animals by genetic means causes premature ISC aging, whereas pharmacological suppression of elevated Cdc42 activity restores organoid formation potential in vitro.
[iScience]
Nalapareddy, K., Hassan, A., Sampson, L., Zheng, Y., & Geiger, H. (2021). Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102362 Cite
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Porcine Colonoids and Enteroids Keep the Memory of Their Origin during Regeneration

Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology]
Barnett, A. M., Mullaney, J. A., Hendriks, C., Le Borgne, L., McNabb, W. C., & Roy, N. (2021). Porcine colonoids and enteroids keep the memory of their origin during regeneration. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00420.2020 Cite
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Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy

The authors studied the impact of chemotherapy on Lgr5-expressing and MSI1-expressing cell populations and explored the effect of increased MSI1 levels in response to treatment.
[Cancer Research]
Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Neve, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., Fouchardière, C. de la, & Plateroti, M. (2021). Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2450 Cite
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The Molecular Underpinning of Geminin-Overexpressing Triple-Negative Breast Cancer Cells Homing Specifically to Lungs

Investigators proposed that geminin overexpression in normal mammary epithelial cells promoted the generation of TNBC metastatic precursors that home specifically to lungs by upregulating LGR5 expression and promoting stemness, intravasation, and extravasation in these precursors.
[Cancer Gene Therapy]
Sami, E., Bogan, D., Molinolo, A., Koziol, J., & ElShamy, W. M. (2021). The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs. Cancer Gene Therapy, 1–22. https://doi.org/10.1038/s41417-021-00311-x Cite
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Twist1 is Required for the Development of UVB‐Induced Squamous Cell Carcinoma

Scientists showed that Twist1 had a direct role in maintaining the balance between proliferation and differentiation of keratinocytes and keratinocyte stem/progenitor populations.
[Molecular Carcinogenesis]
Eguiarte‐Solomon, F., Blazanin, N., Rho, O., Carbajal, S., Felsher, D. W., Tran, P. T., & DiGiovanni, J. (n.d.). Twist1 is required for the development of UVB-induced squamous cell carcinoma. Molecular Carcinogenesis, n/a(n/a). https://doi.org/https://doi.org/10.1002/mc.23296 Cite
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MAP3K2-Regulated Intestinal Stromal Cells Define a Distinct Stem Cell Niche

To determine the physiological role of MAP3K2-regulated intestinal stromal cells (MRISCs), scientists co-cultured MRISCs with colonic organoids and found that organoid growth was greater than when co-cultured with MRISC-depleted stromal cells
[Nature]
Wu, N., Sun, H., Zhao, X., Zhang, Y., Tan, J., Qi, Y., Wang, Q., Ng, M., Liu, Z., He, L., Niu, X., Chen, L., Liu, Z., Li, H.-B., Zeng, Y. A., Roulis, M., Liu, D., Cheng, J., Zhou, B., … Su, B. (2021). MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 1–5. https://doi.org/10.1038/s41586-021-03283-y Cite
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Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet?

The authors summarize currently available adult cell‐derived hepatobiliary organoid models and their applications.
[Hepatology]
Shiota, J., Samuelson, L. C., & Razumilava, N. (n.d.). Hepatobiliary organoids and their applications for studies of liver health and disease: are we there yet? Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31772 Cite
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IL-17B/IL-17RB Signaling Cascade Contributes to Self-Renewal and Tumorigenesis of Cancer Stem Cells by Regulating Beclin-1 Ubiquitination

The authors found that IL-17RB expression was significantly upregulated in spheroid cells and Lgr5-positive cells from the same tumor tissues of patients with gastric cancer, which was closely correlated with the degree of cancer cell differentiation.
[Oncogene]
Bie, Q., Song, H., Chen, X., Yang, X., Shi, S., Zhang, L., Zhao, R., Wei, L., Zhang, B., Xiong, H., & Zhang, B. (2021). IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination. Oncogene, 1–17. https://doi.org/10.1038/s41388-021-01699-4 Cite
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A Constant Pool of Lgr5+ Intestinal Stem Cells Is Required for Intestinal Homeostasis

Using a Lgr5-2A-DTR model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 expression, researchers showed that persistent depletion of Lgr5+ intestinal stem cells in fact compromised small intestinal epithelial integrity and reduced epithelial turnover in vivo.
[Cell Reports]
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Epithelium-Derived Indian Hedgehog Restricts Stromal Expression of ErbB Family Members That Drive Colonic Tumor Cell Proliferation

Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
[Oncogene]
Westendorp, F., Karpus, O. N., Koelink, P. J., Vermeulen, J. L. M., Meisner, S., Koster, J., Büller, N. V. J. A., Wildenberg, M. E., Muncan, V., & van den Brink, G. R. (2021). Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01633-0 Cite
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