MAPK

[Cell Proliferation] Researchers showed the in vitro and in vivo bone-forming ability of chorionic membrane extract (CME) using human osteoblasts and bone defect animal models, suggesting that CME greatly enhanced osteogenesis by providing an osteoconductive environment for the osteogenesis of osteoblasts.

[Translational Oncology] Three patient-derived cancer cells (PDCs) were established from NRAS Q61-positive metastatic melanoma patients. The response of PDCs and five established melanoma cell lines was evaluated toward a panel of 527 oncology drugs using high-throughput drug sensitivity and resistance testing.

[Molecular Cancer Research] Investigators showed that an unanticipated severe tumor phenotype was contributed collectively by severe cholestasis, metabolic changes, upregulated cell cycle progression and disruption of circadian rhythm in mutant hepatocytes.

[Archives of Pharmacal Research] Scientists provided important evidence that kaempferol targeting RSKs might be a strategy to reduce the oxaliplatin-resistant colon cancer cells.

[Laboratory Investigation] Scientists explored the protective effect of vitamin E on chronic obstructive pulmonary disease and the underlying mechanisms.

[Cell Reports] The authors revealed that deoxythymidylate kinase (DTYMK) levels significantly increased and correlated with poor prognosis in hepatocellular carcinoma (HCC).