MAPK

[Archives of Toxicology] In vitro studies, such as DMPO immune-spin trapping assay, and dihydroethidium fluorescence assay on A549 and BEAS-2B cells demonstrated increased oxidative stress due to cobalt exposure.

[Molecular and Cellular Biology] The authors performed a study to explore the effect and mechanism of Alantolactone (ATL) on colorectal cancer. The CCK-8 assay, colony formation assay, Wound-healing and Transwell assays were performed to evaluate the cytotoxic effect, antiproliferative effect, anti-migratory and anti-invasive properties of ATL respectively.

[Carcinogenesis] Researchers investigated the role of CDKN2B-AS1 and the underlying mechanism in human colorectal cancer. Gain- and loss-of-function assays were performed to explore the role of CDKN2B-AS1 in the malignant behavior of HCT116 and SW480 CRC cells in vitro and in vivo.

[Science Signaling] Through mass spectrometry phosphoproteomics, researchers identified heat shock protein 2, which exists as a large oligomer that binds to actin, as a promising candidate for the p38-mediated regulation of barrier integrity.

[Signal Transduction and Targeted Therapy] Scientists found that a combined treatment of local radiofrequency ablation and melatonin greatly improved clinical outcomes for early lung cancer patients with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.

[Scientific Reports] Researchers showed that RKIP inhibited cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activated RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.