The RhoA Dependent Anti-Metastatic Function of RKIP in Breast Cancer

Researchers showed that RKIP inhibited cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activated RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.