MAPK

[Journal of Immunology] Investigators reported that TLR4 was expressed on granulo-monocytic progenitors, as well as mobilized human peripheral blood CD34+ cells. LPS, a component of Gram-negative bacteria that results in a systemic bacterial infection, induced the differentiation of peripheral blood CD34+ cells into myelocytes and monocytes in vitro via the TLR4 signaling pathway.

[SpringWorks Therapeutics, Inc.] SpringWorks Therapeutics, Inc. announced that the company will be evaluating mirdametinib, an investigational MEK inhibitor, in a platform study exploring the compound both as a monotherapy and as a combination therapy in advanced solid tumors harboring MAPK-activating mutations.

[Proceedings of the National Academy of Sciences of the United States of America] Using ex vivo human primary T cells, researchers found that PIP4K activity was required for Treg cell signaling and immunosuppressive activity. Genetic and pharmacological inhibition of PIP4K in Tregs reduced signaling through the PI3K, mTORC1/S6, and MAPK pathways, impaired cell proliferation, and increasedactivation-induced cell death while sparing Tconv.

[Oncogene] Researchers identified fermitin family member 2 as a potential target in A375 cell line by siRNA library screening. They also validated the tumor suppressive role of kindlin-2 was validated in vitro and in vivo.

[Nature Communications] Researchers identified TNFα as a key determinant of paracrine senescence and myeloid-restricted hematopoiesis and showed that its inhibition dampened inflammation, delayed disease onset and rescued hematopoietic defects in bystander cells.

[Free Radical Biology and Medicine] Western blot analysis, flow cytometry, and MitoSOX staining revealed that hyperglycemia-induced mitochondrial oxidative stress production and apoptosis were attenuated in CHIP-overexpressing Wharton's jelly-derived mesenchymal stem cells