PIP4Ks Impact on PI3K, FOXP3, and UHRF1 Signaling and Modulate Human Regulatory T Cell Proliferation and Immunosuppressive Activity

Using ex vivo human primary T cells, researchers found that PIP4K activity was required for Treg cell signaling and immunosuppressive activity. Genetic and pharmacological inhibition of PIP4K in Tregs reduced signaling through the PI3K, mTORC1/S6, and MAPK pathways, impaired cell proliferation, and increasedactivation-induced cell death while sparing Tconv.