PIP4Ks Impact on PI3K, FOXP3, and UHRF1 Signaling and Modulate Human Regulatory T Cell Proliferation and Immunosuppressive Activity

By
Justin.choi
-
0
34
Using ex vivo human primary T cells, researchers found that PIP4K activity was required for Treg cell signaling and immunosuppressive activity. Genetic and pharmacological inhibition of PIP4K in Tregs reduced signaling through the PI3K, mTORC1/S6, and MAPK pathways, impaired cell proliferation, and increasedactivation-induced cell death while sparing Tconv.
[Proceedings of the National Academy of Sciences of the United States of America]
6445218 {6445218:QZL9DKTA} 1 apa 50 default 1 165243 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
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Poli, A., Abdul-Hamid, S., Zaurito, A. E., Campagnoli, F., Bevilacqua, V., Sheth, B., Fiume, R., Pagani, M., Abrignani, S., & Divecha, N. (2021). PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity. Proceedings of the National Academy of Sciences, 118(31). https://doi.org/10.1073/pnas.2010053118 Cite
Abstract