MAPK

[Journal of Natural Products] An in-house library of 2576 plant extracts was screened on two melanoma cell lines with different oncogenic mutations leading to pathological ERK/AKT activity.

[Scientific Reports] MiR-146a alleviated lung injury caused by respiratory syncytial virus (RSV) infection in young rats by targeting TRAF-6 and regulating JNK/ERK/MAPK signaling pathways.

[Cancer Gene Therapy] Investigators unveiled the mechanism underlying long intergenic nonprotein coding RNA 0649 (LINC00649) in lung squamous cell carcinoma (LUSC) cells. As a result, LINC00649 was discovered to be with high expression in LUSC cells.

[Stem Cell Reports] The authors findings supported a direct role for SARS-CoV-2 in mediating endothelial inflammation in an ACE2-dependent or -independent manner.

[Cell Death & Disease] The authors studied the specific function of Numb-PRRL isoform in activated EMT of pancreatic ductal adenocarcinoma, which was distinguished from our previous studies that only focused on the total Numb protein.

[Acta Pharmacologica Sinica] Scientists investigated the protective effect of Dapa against cardiomyopathy caused by high fat diet-induced obesity in vitro and in vivo.