MTOR

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.

[Stem Cell Research & Therapy] Investigators explored the effects of PPARβ/δ agonist on the regeneration of diabetic bone defects and the osteogenic differentiation of rat bone marrow MSCs under a pathological high-glucose condition.

[Cell Death & Disease] Scientists discovered that the T-complex protein 1 (TCP1) expression was elevated in acute myeloid leukemia patients and high TCP1 expression was associated with low complete response rate along with poor overall survival.

[Nature Communications] Investigators showed that the 4-1BB CSD-associated tonic signal yielded a more dramatic effect in CAR-Tregs than in CAR- conventional T cells with respect to activation and proliferation.

[Scientific Reports] In cellular models of Philadelphia Chromosome-positive B-ALL, mTOR kinase inhibitors that inhibit both mTOR-complex-1and mTOR-complex-2 enhanced the cytotoxicity of tyrosine kinase inhibitors such as dasatinib.

[Acta Biochimica et Biophysica Sinica] Researchers evaluated the potential role of epicatechin gallate in prostate cancer cells and found that epicatechin gallate downregulated the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells.