MTOR

[Plant Foods For Human Nutrition] Investigators studied the metabolic effect of resveratrol around the circadian clock in order to determine more accurately the hepatic signaling pathways involved. AML-12 hepatocytes were treated with resveratrol and clock and metabolic markers were measured around the clock.

[Journal of Cellular and Molecular Medicine] The authors explored whether breast cancer cell drug sensitivity to 5-Fu was related to lncRNA CCAT2-regulated mTOR pathway.

[Translational Oncology] The authors summarize the original data obtained from international research laboratories on the oncogenic alterations in each component of the PI3K/Akt/mTOR pathway in lung cancer.

[Science Advances] In this proof-of-concept study, the authors successfully established organoids from seven chordoma tumor samples obtained from five patients presenting with tumors in different sites and stages of disease.

[Biophysical Journal] The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K+]e intracellularly.

[Clinical Cancer Research] Scientists explored the genomic and molecular underpinnings of HCC with increased fluorine-18 fluorodeoxyglucose uptake in positron emission tomography (PET) and identified therapeutic targets based on this imaging-genomic surrogate.