MYC

[Molecular and Cellular Biochemistry] The combined chemotherapy with methionine restriction could enhance the chemotherapeutic sensitivity of colorectal cancer stem cells by up-regulation of miR-320d to inhibit c-Myc expression

[Cancer Gene Therapy] In primary prostate luminal epithelial cells, following inducible oncogenic Kras expression or Pten depletion, TMPRSS2-ERG suppressed oncogene-induced senescence, independent of TP53 induction and RB1 inhibition.

[iScience] Investigators demonstrated that IP3R-mediated Ca2+ signaling and calcineurin regulated B cell proliferation and survival by activating metabolic reprogramming in response to B cell receptor stimulation.

[Molecular Oncology] Targeting ubiquitin carboxyl-terminal hydrolase 28 (USP28) protein abundance at an early stage via inhibition of its activity is a feasible strategy for the treatment of early-stage lung tumors.

[Immunopharmacology and Immunotoxicology] Scientists investigated the effects of miR-222-3p on the formation of medulloblastoma stem-like cells via the Notch2/c-myc pathway.

[Cell Death Discovery] Using iTRAQ-based quantitative proteomics analysis, we identified that nicotinamide N-methyltransferase was significantly increased in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant NSCLC cells.