MYC

[Cell Reports] Scientists showed that Myc-driven hepatocellular carcinoma was dramatically aggravated in mice with hepatocyte-specific Ptpn11/Shp2 deletion.

[Cell Death Discovery] The authors demonstrated that MMP1 derived from tumor-associated macrophages markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.

[Haematologica] The authors showed that, unlike normal B cells, diffuse large B cell lymphoma (DLBCL) cells express abundant levels of transducin b-like protein 1 and its overexpression correlates with poor clinical outcome regardless of DLBCL molecular subtype.

[Sumitomo Dainippon Pharma Oncology, Inc.] Sumitomo Dainippon Pharma Oncology, Inc. announced that the first patient has been dosed in the Phase I dose expansion portion of the study evaluating the investigational agent TP-1287, an oral cyclin-dependent kinase 9 inhibitor, in patients with sarcoma.

[PLoS Genetics] The elevated apoptosis of neural stem/progenitors was recapitulated using Cep55-deficient human cerebral organoids and investigators could rescue the phenotype by inhibiting active Gsk3β.

[Cell Death & Disease] Investigators confirmed that BEZ235 could suppress the proliferation, invasion and colony conformation abilities of intrahepatic cholangiocarcinoma (ICC) cells in vitro but could not effectively inhibit ICC progression in vivo.