NF1

[Oncogene] Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.

[Haematologica] Scientists analyzed the frequency, clinical significance, and prognostic relevance of RAS pathway alterations in 328 pediatric patients with de novo acute myeloid leukemia.

[Scientific Reports] Investigators designed antisense Phosphorodiamidate Morpholino Oligomers to modulate exon 23a alternative splicing at physiological conditions of gene expression and tested their impact during PC12 cell line neuronal differentiation.

[Cancer Research] Scientists isolated labeled mutant oligodendrocyte precursor cells by laser-capture microdissection and determined gene expression changes by bulk RNA sequencing and a fluctuation analysis called stochastic profiling, which used RNA-sequencing measurements from random pools of ten mutant cells.

[Cancer Discovery] Scientists showed that combining a type II RAFi with an allosteric MEKi durably prevents and overcomes acquired resistance among cancers with KRAS, NRAS, NF1, BRAFnon-V600 and BRAFV600 mutations.

[Oncogene] Scientists analyzed a microRNA (miR) microarray comparing with normal and plexiform neurofibroma Schwann cells (PNF-SCs) and identified differences in miR expression, and they validated in mouse PNFs versus normal mouse SCs by qRT-PCR.