Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists analyzed the frequency, clinical significance, and prognostic relevance of RAS pathway alterations in 328 pediatric patients with de novo acute myeloid leukemia.
[Haematologica]
6445212 {6445212:K4U4N6NV} apa 50 1 160305 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-438d6065bdcbc01a908f2be953897c16%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22K4U4N6NV%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kaburagi%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKaburagi%2C%20T.%2C%20Yamato%2C%20G.%2C%20Shiba%2C%20N.%2C%20Yoshida%2C%20K.%2C%20Hara%2C%20Y.%2C%20Tabuchi%2C%20K.%2C%20Shiraishi%2C%20Y.%2C%20Ohki%2C%20K.%2C%20Sotomatsu%2C%20M.%2C%20Arakawa%2C%20H.%2C%20Matsuo%2C%20H.%2C%20Shimada%2C%20A.%2C%20Taki%2C%20T.%2C%20Kiyokawa%2C%20N.%2C%20Tomizawa%2C%20D.%2C%20Horibe%2C%20K.%2C%20Miyano%2C%20S.%2C%20Taga%2C%20T.%2C%20Adachi%2C%20S.%2C%20%26%23x2026%3B%20Hayashi%2C%20Y.%20%282020%29.%20Clinical%20significance%20of%20RAS%20pathway%20alterations%20in%20pediatric%20acute%20myeloid%20leukemia.%20%3Ci%3EHaematologica%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3324%5C%2Fhaematol.2020.269431%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3324%5C%2Fhaematol.2020.269431%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DK4U4N6NV%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20significance%20of%20RAS%20pathway%20alterations%20in%20pediatric%20acute%20myeloid%20leukemia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taeko%22%2C%22lastName%22%3A%22Kaburagi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genki%22%2C%22lastName%22%3A%22Yamato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norio%22%2C%22lastName%22%3A%22Shiba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenichi%22%2C%22lastName%22%3A%22Yoshida%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yusuke%22%2C%22lastName%22%3A%22Hara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ken%22%2C%22lastName%22%3A%22Tabuchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuichi%22%2C%22lastName%22%3A%22Shiraishi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kentaro%22%2C%22lastName%22%3A%22Ohki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manabu%22%2C%22lastName%22%3A%22Sotomatsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hirokazu%22%2C%22lastName%22%3A%22Arakawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hidemasa%22%2C%22lastName%22%3A%22Matsuo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akira%22%2C%22lastName%22%3A%22Shimada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomohiko%22%2C%22lastName%22%3A%22Taki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nobutaka%22%2C%22lastName%22%3A%22Kiyokawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisuke%22%2C%22lastName%22%3A%22Tomizawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keizo%22%2C%22lastName%22%3A%22Horibe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Satoru%22%2C%22lastName%22%3A%22Miyano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Takashi%22%2C%22lastName%22%3A%22Taga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Souichi%22%2C%22lastName%22%3A%22Adachi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seishi%22%2C%22lastName%22%3A%22Ogawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuhide%22%2C%22lastName%22%3A%22Hayashi%22%7D%5D%2C%22abstractNote%22%3A%22RAS%20pathway%20alterations%20have%20been%20implicated%20in%20the%20pathogenesis%20of%20various%20hematological%20malignancies.%20However%2C%20their%20clinical%20relevance%20in%20pediatric%20acute%20myeloid%20leukemia%20%28AML%29%20is%20not%20well%20characterized.%20We%20analyzed%20the%20frequency%2C%20clinical%20significance%2C%20and%20prognostic%20relevance%20of%20RAS%20pathway%20alterations%20in%20328%20pediatric%20patients%20with%20de%20novo%20AML.%20RAS%20pathway%20alterations%20were%20detected%20in%2080%20%2824.4%25%29%20out%20of%20328%20patients%3A%20NF1%20%28n%20%3D%207%2C%202.1%25%29%2C%20PTPN11%20%28n%20%3D%2015%2C%204.6%25%29%2C%20CBL%20%28n%20%3D%206%2C%201.8%25%29%2C%20NRAS%20%28n%20%3D%2044%2C%2013.4%25%29%2C%20KRAS%20%28n%20%3D%2012%2C%203.7%25%29.%20Most%20of%20these%20alterations%20were%20mutually%20exclusive%20and%20were%20also%20mutually%20exclusive%20with%20other%20aberrations%20of%20signal%20transduction%20pathways%20such%20as%20FLT3-ITD%20%28p%20%3D%200.001%29%20and%20KIT%20mutation%20%28p%20%3D%200.004%29.%20NF1%20alterations%20were%20frequently%20detected%20in%20patients%20with%20complex%20karyotype%20%28p%20%3D%200.031%29%20and%20were%20found%20to%20be%20independent%20predictors%20of%20poor%20overall%20survival%20%28OS%29%20in%20multivariate%20analysis%20%28p%20%3D%200.007%29.%20At%20least%20four%20of%20seven%20patients%20with%20NF1%20alterations%20had%20bi-allelic%20inactivation.%20NRAS%20mutations%20were%20frequently%20observed%20in%20patients%20with%20CBFB-MYH11%20and%20were%20independent%20predictors%20of%20favorable%20outcomes%20in%20multivariate%20analysis%20%5BOS%2C%20p%20%3D%200.023%3B%20event-free%20survival%20%28EFS%29%2C%20p%20%3D%200.037%5D.%20Patients%20with%20PTPN11%20mutations%20more%20frequently%20received%20stem%20cell%20transplantation%20%28p%20%3D%200.035%29%20and%20showed%20poor%20EFS%20than%20patients%20without%20PTPN11%20mutations%20%28p%20%3D%200.013%29.%20Detailed%20analysis%20of%20RAS%20pathway%20alterations%20may%20enable%20a%20more%20accurate%20prognostic%20stratification%20of%20pediatric%20AML%20and%20may%20provide%20novel%20therapeutic%20molecular%20targets%20related%20to%20this%20signal%20transduction%20pathway.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3324%5C%2Fhaematol.2020.269431%22%2C%22ISSN%22%3A%221592-8721%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fhaematologica.org%5C%2Farticle%5C%2Fview%5C%2Fhaematol.2020.269431%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-19T16%3A42%3A06Z%22%7D%7D%5D%7D
Kaburagi, T., Yamato, G., Shiba, N., Yoshida, K., Hara, Y., Tabuchi, K., Shiraishi, Y., Ohki, K., Sotomatsu, M., Arakawa, H., Matsuo, H., Shimada, A., Taki, T., Kiyokawa, N., Tomizawa, D., Horibe, K., Miyano, S., Taga, T., Adachi, S., … Hayashi, Y. (2020). Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia. Haematologica. https://doi.org/10.3324/haematol.2020.269431 Cite
