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Nanog

Dinaciclib Inhibits the Stemness of Two Subtypes of Human Breast Cancer Cells by Targeting the FoxM1 and Hedgehog Signaling Pathway

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

Local Anesthetic Levobupivacaine Inhibits Stemness of Osteosarcoma Cells by Epigenetically Repressing MAFB Though Reducing KAT5 Expression

[Aging] Scientists identified that the treatment of levobupivacaine suppressed proliferation of osteosarcoma cells in vitro.

Ubiquitin-Specific Protease 1 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Doxorubicin by Ubiquitinated Proliferating Cell Nuclear Antigen–Mediated Attenuation of Stemness

[Anti-Cancer Drugs] Scientists investigate the effect of Ubiquitin-specific protease 1 (USP1) depletion with chemotherapeutant doxorubicin on the hepatocellular carcinoma cells.

Synergistic Combination of PMBA and 5-Fluorouracil (5-FU) in Targeting Mutant KRAS in 2D and 3D Colorectal Cancer Cells

[Heliyon] Scientists investigated the effect and efficacy of 2-pyridin-4-yl methylene β-boswellic acid (PMBA) and 5-FU in combination therapy compared in the treatment of KRAS mutant colon cancer.

Claudin1 Decrease Induced by 1,25-Dihydroxy-Vitamin D3 Potentiates Gefitinib Resistance Therapy through Inhibiting AKT Activation-Mediated Cancer Stem-Like Properties in NSCLC Cells

[Cell Death Discovery] Researchers performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in NSCLC cells.

MicroRNA-135 Inhibits Initiation of Epithelial-Mesenchymal Transition in Breast Cancer by Targeting ZNF217 and Promoting m6A Modification of NANOG

[Oncogene] Scientists highlighted the role of the miR-135/zinc finger protein 217 (ZNF217)/methyltransferase-like 13/NANOG axis in the progression of breast cancer (BC), emphasizing potential therapeutic targets ZNF217 silencing and miR-135 upregulation in preventing or treating BC.

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