Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease]
The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
Researchers identified a clinically relevant signaling nexus mediated by AXL receptor, PYK2 and PKCα and show its impact on stemness in triple-negative breast cancer.
[Life Science Alliance]
The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
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Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]
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Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J. P., & Tanaka, S. (2021). Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering, 1–12. https://doi.org/10.1038/s41551-021-00692-2 Cite
Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
Investigators show that endogenous suppression of WNT signalling in hPSCs at the onset of differentiation prevented the switch from self-renewal to definitive endoderm specification.
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Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm | Scientific Reports. (n.d.). Retrieved March 17, 2021, from https://www.nature.com/articles/s41598-021-85447-4 Cite
Cancer stem cells capacities were evaluated regarding capacity to form spheres, expression of stem cell markers and the presence of ALDHhigh cells.
Scientists characterized and identify a subpopulation of CD133+ cancer stem-like cells derived from SK-UT-1 cell line.
[Cancer Cell International]
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Gao, J., Yang, T., Wang, X., Zhang, Y., Wang, J., Zhang, B., Tang, D., Liu, Y., Gao, T., Lin, Q., Tang, J., & Cai, J. (2021). Identification and characterization of a subpopulation of CD133+ cancer stem‐like cells derived from SK-UT-1 cells. Cancer Cell International, 21(1), 157. https://doi.org/10.1186/s12935-021-01817-y Cite
Investigators proposed that Npac is essential for transcriptional elongation of pluripotency genes by recruiting of p-TEFb and interacting with RNA Pol II Ser2 and Ser5.
[Genomics Proteomics & Bioinformatics]
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The authors identified E26 transformation-specific homologous factor as a key molecule in decreasing the sensitivity of pancreatic cancer cells to cancer stem cells’ niche stimulus.
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Zhou, T., Liu, J., Xie, Y., Yuan, S., Guo, Y., Bai, W., Zhao, K., Jiang, W., Wang, H., Wang, H., Zhao, T., Huang, C., Gao, S., Wang, X., Yang, S., & Hao, J. (2021). ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4. Gut. https://doi.org/10.1136/gutjnl-2020-321952 Cite