Escherichia coli Foster Bladder Cancer Cell Line Progression via Epithelial Mesenchymal Transition, Stemness and Metabolic Reprogramming

In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
[Scientific Reports]
Abd-El-Raouf, R., Ouf, S. A., Gabr, M. M., Zakaria, M. M., El-Yasergy, K. F., & Ali-El-Dein, B. (2020). Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming. Scientific Reports, 10(1), 18024. https://doi.org/10.1038/s41598-020-74390-5 Cite
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Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo

Endogenous tagging of Nanog in ESCs revealed that ERK inhibition promoted enhanced stabilization of NANOG protein after mitosis. Scientists showed that cell cycle, signaling, and differentiation are coordinated during preimplantation development.
[Developmental Cell]
Pokrass, M. J., Ryan, K. A., Xin, T., Pielstick, B., Timp, W., Greco, V., & Regot, S. (2020). Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.09.013 Cite
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ROS-Mediated Genotoxic Stress Is Involved in NaAsO2-Induced Cell Cycle Arrest, Stemness Enhancement and Chemoresistance of Prostate Cancer Cells in a p53-Independent Manner

The authors suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
[Ecotoxicology and Environmental Safety]
Zhang, Z.-H., Hong, Q., Zhang, Z.-C., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q.-L., Wang, H., Yu, D.-X., Xie, D.-D., & Xu, D.-X. (2021). ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicology and Environmental Safety, 208, 111436. https://doi.org/10.1016/j.ecoenv.2020.111436 Cite
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On the Road Again – Establishment and Maintenance of Stemness in the Neural Crest from Embryo to Adulthood

The neural crest (NC) is an ESC population that contributes to a greatly expanding list of derivatives ranging from neurons and glia of the peripheral nervous system, facial cartilage and bone, pigment cells of the skin to secretory cells of the endocrine system. Scientists focus on what is specifically known about establishment and maintenance of NC stemness and ultimate fate commitment mechanisms.
[Stem Cells]
Perera, S. N., & Kerosuo, L. (n.d.). On the road again – establishment and maintenance of stemness in the neural crest from embryo to adulthood. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3283 Cite
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Xeno- and Transgene-Free Reprogramming of Mesenchymal Stem Cells Toward the Cells Expressing Neural Markers Using Exosome Treatments

Scientists demonstrated that treatment with exosomes derived from neural stem cells makes MSCs capable of expressing neural cell markers bypassing the generation of iPSCs.
[PLoS One]
Valerio, L. S. A., & Sugaya, K. (2020). Xeno- and transgene-free reprogramming of mesenchymal stem cells toward the cells expressing neural markers using exosome treatments. PLOS ONE, 15(10), e0240469. https://doi.org/10.1371/journal.pone.0240469 Cite
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Identification of a Dynamic Gene Regulatory Network Required for Pluripotency Factor-Induced Reprogramming of Mouse Fibroblasts and Hepatocytes

The authors investigated the early transcriptional events of cellular reprogramming triggered by the co‐expression of Oct4, Sox2, Klf4, and c‐Myc in mouse embryonic fibroblasts and mouse hepatocytes.
[EMBO Journal]
Papathanasiou, M., Tsiftsoglou, S. A., Polyzos, A. P., Papadopoulou, D., Valakos, D., Klagkou, E., Karagianni, P., Pliatska, M., Talianidis, I., Agelopoulos, M., & Thanos, D. (2020). Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. The EMBO Journal, n/a(n/a), e102236. https://doi.org/10.15252/embj.2019102236 Cite
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LncRNA HotairM1 Depletion Promotes Self-Renewal of Cancer Stem Cells Through HOXA1-Nanog Regulation Loop

Based on analysis of transcriptome sequencing, researchers identified a long noncoding RNA (lncRNA) named HotairM1 that was weakly expressed in human colorectal carcinoma and uveal melanoma, and a much lower expression in corresponding CSCs.
[Molecular Therapy-Nucleic Acids]
Li, F., Xu, Y., Xu, X., Ge, S., Zhang, F., Zhang, H., & Fan, X. (2020). LncRNA HotairM1 Depletion Promotes Self-Renewal of Cancer Stem Cells through HOXA1-Nanog regulation loop. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.008 Cite
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Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma

Researchers investigated changes in expression levels of the cancer stem cell (CSC) biomarker, cluster of differentiation 133 (CD133), from primary ovarian cancer (OC) cell lines to induction of CSC-spheres in an attempt to explore the mechanisms related to modulation of stemness, drug resistance, and tumorigenesis in CSCs, thus facilitating the search for new therapeutics for OC.
[International Journal of Molecular Sciences]
Liu, C. L., Chen, Y. J., Fan, M. H., Liao, Y. J., & Mao, T. L. (2020). Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma. International Journal of Molecular Sciences, 21(18), 6467. https://doi.org/10.3390/ijms21186467 Cite
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1,25-Dihydroxyvitamin D3 Signaling-Induced Decreases in IRX4 Inhibits NANOG-Mediated Cancer Stem-Like Properties and Gefitinib Resistance in NSCLC Cells

Researchers discovered that increased iroquois-class homeodomain protein 4 (IRX4) was related to gefitinib resistance in non-small cell lung cancer (NSCLC) cells. Knockdown of IRX4 inhibited cell proliferation, sphere formation, and the expression of CD133, ALDH1A1, NANOG, Sox2 and Notch1, and the transcriptional activity of NANOG promoter.
[Cell Death & Disease]
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SOSTDC1 Promotes Invasion and Liver Metastasis in Colorectal Cancer via Interaction with ALCAM/CD166

Researchers demonstrated that sclerostin domain containing-1 promoted invasion and liver metastasis in colorectal cancer, by overcoming BMP4-specific antimetastatic signals and inducing ALCAM-mediated Src and PI3K/AKT activation.
[Oncogene]
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In Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features

Researchers compared the effects of tyrosine kinase inhibitors belonging to different generations, imatinib and ponatinib, on progenitor/stem cell expansion potential and markers.
[Targeted Oncology]
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