To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
[Cell Death & Disease]
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Yoon, C., Lu, J., Ryeom, S. W., Simon, M. C., & Yoon, S. S. (2021). PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance. Cell Death & Disease, 12(8), 1–11. https://doi.org/10.1038/s41419-021-04036-5 Cite
The authors investigated whether ESCs retained memory of their previous states or transition in a memoryless (Markovian) process, and showed that some highly dynamic lineages of ESCs did not exhibit the Markovian property: their previous states and kin relations influenced future choices.
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The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.
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Scientists evaluated the NANOG inhibition by siRNA and the increase of Let-7a by miRNA mimic in breast cancer cell lines and the effects of these changes on biologic aspects like apoptosis, stemness and invasion of these cells.
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Scientists investigated the Regorafenib resistance mechanism of CSCs in hepatocellular carcinoma. They used sphere formation and soft agar colony formation assays to evaluate the stemness capacity of cancer cells.
[Journal of Gastroenterology and Hepatology]
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Researchers compared the cytoprotection between peritoneal dialysis (PD) effluent-derived MSCs and umbilical cord-derived MSCs in the treatment of both peritoneal membrane and kidney injury in uremic rats with chronic PD.
[Stem Cell Research & Therapy]
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Du, Y., Zong, M., Guan, Q., Huang, Z., Zhou, L., Cai, J., da Roza, G., Wang, H., Qi, H., Lu, Y., & Du, C. (2021). Comparison of mesenchymal stromal cells from peritoneal dialysis effluent with those from umbilical cords: characteristics and therapeutic effects on chronic peritoneal dialysis in uremic rats. Stem Cell Research & Therapy, 12(1), 398. https://doi.org/10.1186/s13287-021-02473-9 Cite
The authors showed that conditional Satb2 gene inactivation weakened ESC pluripotency, and identified SUMO2 modification of SATB2 by the E3 ligase ZFP451 as a potential driver of ESC differentiation.
[Genes & Development]
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Long non-coding RNAs and miRs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Investigators explored the underlying roles of LINC00115 and miR-30a in OC.
[Cancer Cell International]
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Investigators demonstrated that ZEB2, the transcription factor of epithelial–mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.
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Researchers developed a rapid protein-level OCT4 depletion system that demonstrated that the immediate downstream response to loss of OCT4 was reduced expression of key pluripotency factors.
[Stem Cell Reports]
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The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.
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