TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy–Lysosomal Biogenesis

Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease]
Tan, A., Prasad, R., & Jho, E. (2021). TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03632-9 Cite
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Induced Pluripotent Stem Cell Technology: Trends in Molecular Biology, from Genetics to Epigenetics

The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
[Epigenomics]
Maali, A., Maroufi, F., Sadeghi, F., Atashi, A., Kouchaki, R., Moghadami, M., & Azad, M. (2021). Induced pluripotent stem cell technology: trends in molecular biology, from genetics to epigenetics. Epigenomics. https://doi.org/10.2217/epi-2020-0409 Cite
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The AXL-PYK2-PKCα Axis as a Nexus of Stemness Circuits in TNBC

Researchers identified a clinically relevant signaling nexus mediated by AXL receptor, PYK2 and PKCα and show its impact on stemness in triple-negative breast cancer.
[Life Science Alliance]
Khera, L., Vinik, Y., Maina, F., & Lev, S. (2021). The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC. Life Science Alliance, 4(6). https://doi.org/10.26508/lsa.202000985 Cite
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]
Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J. P., & Tanaka, S. (2021). Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering, 1–12. https://doi.org/10.1038/s41551-021-00692-2 Cite
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The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells

Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
[Biochemical Genetics]
Farahani, D. B., Akrami, H., Moradi, B., Mehdizadeh, K., & Fattahi, M. R. (2021). The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical Genetics. https://doi.org/10.1007/s10528-021-10057-8 Cite
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Endogenous Suppression of WNT Signalling in Human Embryonic Stem Cells Leads to Low Differentiation Propensity Towards Definitive Endoderm

Investigators show that endogenous suppression of WNT signalling in hPSCs at the onset of differentiation prevented the switch from self-renewal to definitive endoderm specification.
[Scientific Reports]
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm | Scientific Reports. (n.d.). Retrieved March 17, 2021, from https://www.nature.com/articles/s41598-021-85447-4 Cite
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Acquisition of Cancer Stem Cell Capacities after Spontaneous Cell Fusion

Cancer stem cells capacities were evaluated regarding capacity to form spheres, expression of stem cell markers and the presence of ALDHhigh cells.
[BMC Cancer]
Merle, C., Lagarde, P., Lartigue, L., & Chibon, F. (2021). Acquisition of cancer stem cell capacities after spontaneous cell fusion. BMC Cancer, 21(1), 241. https://doi.org/10.1186/s12885-021-07979-2 Cite
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Identification and Characterization of a Subpopulation of CD133+ Cancer Stem-Like Cells Derived from SK-UT-1 Cells

Scientists characterized and identify a subpopulation of CD133+ cancer stem-like cells derived from SK-UT-1 cell line.
[Cancer Cell International]
Gao, J., Yang, T., Wang, X., Zhang, Y., Wang, J., Zhang, B., Tang, D., Liu, Y., Gao, T., Lin, Q., Tang, J., & Cai, J. (2021). Identification and characterization of a subpopulation of CD133+ cancer stem‐like cells derived from SK-UT-1 cells. Cancer Cell International, 21(1), 157. https://doi.org/10.1186/s12935-021-01817-y Cite
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Npac is a Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells

Investigators proposed that Npac is essential for transcriptional elongation of pluripotency genes by recruiting of p-TEFb and interacting with RNA Pol II Ser2 and Ser5.
[Genomics Proteomics & Bioinformatics]
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ESE3/EHF, a Promising Target of Rosiglitazone, Suppresses Pancreatic Cancer Stemness by Downregulating CXCR4

The authors identified E26 transformation-specific homologous factor as a key molecule in decreasing the sensitivity of pancreatic cancer cells to cancer stem cells’ niche stimulus.
[Gut]
Zhou, T., Liu, J., Xie, Y., Yuan, S., Guo, Y., Bai, W., Zhao, K., Jiang, W., Wang, H., Wang, H., Zhao, T., Huang, C., Gao, S., Wang, X., Yang, S., & Hao, J. (2021). ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4. Gut. https://doi.org/10.1136/gutjnl-2020-321952 Cite
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