miR-3065-3p Promotes Stemness and Metastasis by Targeting CRLF1 in Colorectal Cancer

The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.
[Journal of Translational Medicine]
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MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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Regulation of NANOG and SOX2 Expression by Activin A and a Canonical WNT Agonist in Bovine Embryonic Stem Cells and Blastocysts

Activation of activin A signaling stimulated NANOG expression during self-renewal of bovine ESC but suppressed cells expressing pluripotency markers in the blastocyst and increased cells expressing CDX2.
[Biology Open]
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Atypical Cyclin P Regulates Cancer Cell Stemness through Activation of the WNT Pathway

Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.
[Cellular Oncology]
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miR-27b Antagonizes BMP Signaling in Early Differentiation of Human Induced Pluripotent Stem Cells

Researchers used miR-27b-inducible human iPSCs (hiPSCs) to investigate the roles of miR-27b in the undifferentiated and early-differentiated stages. In undifferentiated hiPSCs, miR-27b suppressed the expression of pluripotency markers and cell proliferation.
[Scientific Reports]
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Loss of Resf1 Reduces the Efficiency of Embryonic Stem Cell Self-Renewal and Germline Entry

The authors used Resf1 knockout cell lines to determine the requirements of RESF1 for ESC self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells
[Life Science Alliance]
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The ETS Transcription Factor ERF Controls the Exit from the Naïve Pluripotent State in a MAPK-Dependent Manner

The authors examined the molecular mechanisms coordinating the naïve to primed transition by using inducible ESC to genetically eliminate all RAS proteins. They showed that differentiated RASKO ESCs remained trapped in an intermediate state of pluripotency with naïve-associated features.
[Science Advances]
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HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
[Cell Reports]
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Stereospecific Inhibition of AMPK by (R)-Crizotinib Induced Changes to the Morphology and Properties of Cancer and Cancer Stem Cell-Like Cells

While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.
[European Journal of Pharmacology]
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Effects of 2,2′,4,4′-Tetrabromodiphenyl Ether on the Development of Mouse Embryonic Stem Cells

To explore the developmental toxicity of 2,2′,4,4′-Tetrabromodiphenyl ether (BDE47), mouse ESCs, which are ideal models for testing the developmental toxicity of environmental contaminants in vitro, were exposed to BDE47 for 24 h or 48 h in this study.
[Reproductive Toxicology]
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RASSF1C Oncogene Elicits Amoeboid Invasion, Cancer Stemness, and Extracellular Vesicle Release via a SRC/Rho Axis

Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.
[EMBO Journal]
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