Researchers investigated how glioma initiating cells invaded 3D hydrogels in response to an interstitial flow with respect to their differentiation status. Microfluidic culture systems were used to apply an interstitial flow to the cells migrating from the cell aggregates into the 3D hydrogel.
[Tissue Engineering Part A]
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Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
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Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling | SpringerLink. (n.d.). Retrieved February 17, 2021, from https://link.springer.com/article/10.1007%2Fs00262-021-02872-0 Cite
Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
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Glioblastoma cells that are part of the tumor microtube-connected tumor network showed activated neurodevelopmental and glioma progression gene expression pathways. Importantly, many of them revealed profiles indicative of increased cellular stemness, including high expression of nestin.
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Xie, R., Kessler, T., Grosch, J., Hai, L., Venkataramani, V., Huang, L., Hoffmann, D. C., Solecki, G., Ratliff, M., Schlesner, M., Wick, W., & Winkler, F. (2020). Tumor cell network integration in glioma represents a stemness feature. Neuro-Oncology, noaa275. https://doi.org/10.1093/neuonc/noaa275 Cite
Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.
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Proteomic analyses of human angiogenesis-related factors produced by human adipose tissue-derived stromal/stem cells (hADSCs) showed that both pro- and anti-angiogenic factors were produced by hADSCs in vitro, but only those related to vessel maturation were detectable in vivo.
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Menezes, K., Rosa, B. G., Freitas, C., da Cruz, A. S., de Siqueira Santos, R., Nascimento, M. A., Alves, D. V. L., Bonamino, M., Rossi, M. I., Borojevic, R., & Coelho-Sampaio, T. (2020). Human mesenchymal stromal/stem cells recruit resident pericytes and induce blood vessels maturation to repair experimental spinal cord injury in rats. Scientific Reports, 10(1), 19604. https://doi.org/10.1038/s41598-020-76290-0 Cite
Researchers identified brain specific expression of a novel C3G isoform in mice and humans. This isoform has an insert in the Crk-binding region, generating a polypeptide of 175 kDa, unlike the previously known 140 kDa form expressed in all other tissues.
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Expression of a novel brain specific isoform of C3G is regulated during development | Scientific Reports. (n.d.). Retrieved November 2, 2020, from https://www.nature.com/articles/s41598-020-75813-z Cite
The authors report a protocol that efficiently induced near synchronous rosette organization, even from human PSC-derived neural progenitor cell monolayers that do not generally exhibit rosette formation using previously existing protocols.
[Frontiers in Cell and Developmental Biology]
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Townshend, R. F., Shao, Y., Wang, S., Cortez, C. L., Esfahani, S. N., Spence, J. R., O’Shea, K. S., Fu, J., Gumucio, D. L., & Taniguchi, K. (2020). Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.588941 Cite
Investigators studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
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Forte, D., García-Fernández, M., Sánchez-Aguilera, A., Stavropoulou, V., Fielding, C., Martín-Pérez, D., López, J. A., Costa, A. S. H., Tronci, L., Nikitopoulou, E., Barber, M., Gallipoli, P., Marando, L., Castillejo, C. L. F. de, Tzankov, A., Dietmann, S., Cavo, M., Catani, L., Curti, A., … Méndez-Ferrer, S. (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.09.001 Cite
The authors studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
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Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
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Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite