The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
[Cell Death & Disease]
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Schwann Cells Promote Prevascularization and Osteogenesis of Tissue-Engineered Bone via Bone Marrow Mesenchymal Stem Cell-Derived Endothelial Cells

The authors cultured rat Schwann cells, aortic endothelial cells, and bone marrow-derived mesenchymal stem cells (BM-MSCs) and then obtained BM-MSC-derived induced endothelial cells and induced osteoblasts.
[Stem Cell Research & Therapy]
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Matrigel Enhances Differentiation of Human Adipose Tissue-Derived Stem Cells Into Dopaminergic Neuron

The authors investigated the differentiation capacity of human adult MSCs derived from adipose tissue into dopaminergic and neuron-like cells in the 3D culture plate.
[Neuroscience Letters]
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Adult Neural Stem Cells Have Latent Inflammatory Potential That Is Kept Suppressed by Tcf4 to Facilitate Adult Neurogenesis

we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (Tcf4).
[Science Advances]
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Stem-Like Cells Drive NF1-Associated MPNST Functional Heterogeneity and Tumor Progression

Investigators discovered and characterized a rare malignant peripheral nerve sheath tumor (MPNST) cell population with stem-cell-like properties, including quiescence, that was essential for tumor initiation and relapse.
[Cell Stem Cell]
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Bone Marrow NG2+/Nestin+ Mesenchymal Stem Cells Drive DTC Dormancy via TGF-β2

Researchers revealed that periarteriolar bone marrow-resident NG2+/Nestin+ mesenchymal stem cells can also instruct breast cancer disseminated tumor cells to enter dormancy.
[Nature Cancer]
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Heterogeneous Glioma Cell Invasion under Interstitial Flow Depending on Their Differentiation Status

Researchers investigated how glioma initiating cells invaded 3D hydrogels in response to an interstitial flow with respect to their differentiation status. Microfluidic culture systems were used to apply an interstitial flow to the cells migrating from the cell aggregates into the 3D hydrogel.
[Tissue Engineering Part A]
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Regulatory T Cells Promote Glioma Cell Stemness through TGF-β–NF-κB–IL6–STAT3 Signaling

Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
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Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression

Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
[Cell Reports]
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Tumor Cell Network Integration in Glioma Represents a Stemness Feature

Glioblastoma cells that are part of the tumor microtube-connected tumor network showed activated neurodevelopmental and glioma progression gene expression pathways. Importantly, many of them revealed profiles indicative of increased cellular stemness, including high expression of nestin.
[Neuro-Oncology]
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PARK7 Maintains the Stemness of Glioblastoma Stem Cells by Stabilizing Epidermal Growth Factor Receptor Variant III

Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.
[Oncogene]
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