Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
[Cell Death & Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
The authors cultured rat Schwann cells, aortic endothelial cells, and bone marrow-derived mesenchymal stem cells (BM-MSCs) and then obtained BM-MSC-derived induced endothelial cells and induced osteoblasts.
[Stem Cell Research & Therapy]
[zotpress userid=’6445218′ items=’WZCKCX5Z’ style=’apa’ cite=’yes’]
The authors investigated the differentiation capacity of human adult MSCs derived from adipose tissue into dopaminergic and neuron-like cells in the 3D culture plate.
[zotpress userid=” items=’8R4MDEWE’ style=’apa’ cite=’yes’]
we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (Tcf4).
[zotpress userid=’7753456′ items=’U42RECZ2′ style=’apa’ cite=’yes’]
Investigators discovered and characterized a rare malignant peripheral nerve sheath tumor (MPNST) cell population with stem-cell-like properties, including quiescence, that was essential for tumor initiation and relapse.
[Cell Stem Cell]
[zotpress userid=” items=’HJ445PC8′ style=’apa’ cite=’yes’]
Researchers revealed that periarteriolar bone marrow-resident NG2+/Nestin+ mesenchymal stem cells can also instruct breast cancer disseminated tumor cells to enter dormancy.
[zotpress userid=’1254621′ items=’GQ75KPZM’ style=’apa’ cite=’yes’]
Researchers investigated how glioma initiating cells invaded 3D hydrogels in response to an interstitial flow with respect to their differentiation status. Microfluidic culture systems were used to apply an interstitial flow to the cells migrating from the cell aggregates into the 3D hydrogel.
[Tissue Engineering Part A]
[zotpress userid=’6445212′ items=’M3I8M24S’ style=’apa’ cite=’yes’]
Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
[zotpress userid=’6445218′ items=’L78X9JVH’ style=’apa’ cite=’yes’]
Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
[zotpress userid=’6807162′ items=’E3G4JI4B’ style=’apa’ cite=’yes’]
Glioblastoma cells that are part of the tumor microtube-connected tumor network showed activated neurodevelopmental and glioma progression gene expression pathways. Importantly, many of them revealed profiles indicative of increased cellular stemness, including high expression of nestin.
[zotpress userid=’6807162′ items=’96XKFUNE’ style=’apa’ cite=’yes’]
Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.
[zotpress userid=’6807162′ items=’H6D6MYZZ’ style=’apa’ cite=’yes’]