PBMCs

[Heliyon] The authors developed PRAK-03202, the world’s first triple antigen virus-like particle vaccine candidate, by cloning and transforming SARS-CoV-2 gene segments into a highly characterized S. cerevisiae-based D-Crypt™ platform, which induced SARS CoV-2 specific neutralizing antibodies in BALB/c mice.

[Stem Cell Research] Scientists generated iPSCs from a normal individual by electroporation of peripheral blood mononuclear cells, and further generated a SCN1B-knockout human iPSC line via CRISPR/Cas9 gene editing.

[Frontiers in Immunology] Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.

[BMC Cancer] The effects of interference with eIF5B expression on the growth, morphology, and immunity of the tumor, as well as PD-L1 expression in the tumor, were verified by tumor xenograft assays in vivo.

[Scientific Reports] The authors determined toll-like receptor (TLR) expression patterns in peripheral blood mononuclear cells of non-alcoholic fatty liver disease (NAFLD) patients and controls, their relation to intestinal microbiota and the impact of TLRs found altered in NAFLD development.

[Stem Cell Research & Therapy] Modified mixed leukocyte reaction was performed between feline adipose-derived MSCs and PBMCs. Changes of cell cycle stages, phenotype and cellular senescence were determined through flow cytometry and gene expression analysis.