PBMCs

[Clinical infectious Diseases] The authors investigated cellular immune responses up to five years after infection in a cohort of 59 Middle East respiratory syndrome survivors by performing ELISPOT assay and intracellular cytokine staining after stimulation of peripheral blood mononuclear cells with synthetic viral peptides.

[Stem Cell Research & Therapy] Direct and indirect co-cultures between dental pulp stem cells (DPSCs) and peripheral blood mononuclear cells (PBMCs) were carried out to evaluate the activation of immunomodulatory checkpoints in DPSCs and the inflammatory pattern in PBMCs.

[Cytotherapy] The allorejection of MSCs indicates that they are not fully immune-privileged. The authors investigated the immunogenicity of human adipose-derived MSCs and identified potential immunogenic molecules.

[Scientific Reports] Researchers showed that in mice and humans there was a spliced variant of p65, named p65 iso5, which bound the corticosteroid hormone dexamethasone amplifying the effect of the glucocorticoid receptor and was expressed in the liver of patients with hepatic cirrhosis and hepatocellular carcinoma.

[Science Advances] Scientists found a remarkable activation of type I interferon (IFN-I) signaling in whole blood, peripheral blood mononuclear cells, monocytes, and serum from patients with OTULIN deficiency.

[iScience] Analysis of eight single-cells RNA-seq datasets from peripheral blood mononuclear cells, nasopharyngeal samples and Broncho alveolar lavage fluid, revealed significantly reduced mtDNA gene expression especially in immune system cells from patients.