PD-L1

[Cancer Communications] Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice. Bioluminescence imaging, flow cytometry, and immunohistochemistry were employed to determine response to immunotherapy and function of tumor-infiltrating immune cells.

[Immunobiology] The authors explored the function and mechanism of LINC00184 in docetaxel resistance of prostate cancer and found that LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulting in upregulation of the expression of PD-L1.

[Bioengineered] Analysis of a dataset verified the prognostic value of PD-L1 and revealed an association between PD-L1 mRNA expression and the status of isocitrate dehydrogenase. Increased PD-L1 expression predicts unfavorable overall survival in glioblastoma.

[Journal of Cellular and Molecular Medicine] Researchers developed a 6-gene immune-related risk model to predict the survival of patients with lung adenocarcinoma (LUAD) in The Cancer Genome Atlas cohort based on TP53 status, and the predictive ability was confirmed in two independent cohorts.

[Stem Cell Research & Therapy] Direct and indirect co-cultures between dental pulp stem cells (DPSCs) and peripheral blood mononuclear cells (PBMCs) were carried out to evaluate the activation of immunomodulatory checkpoints in DPSCs and the inflammatory pattern in PBMCs.

[Oncogene] Scientists found that the 18fluoro-deoxyglucose positron emission tomography/computed tomography-based markers were positively associated with the expression of programmed cell death ligand 1, pyruvate kinase M2, both of which indicate poor prognosis in patients with pancreatic ductal adenocarcinoma.