Anti-PD-L1/TGF-βR Fusion Protein (SHR-1701) Overcomes Disrupted Lymphocyte Recovery-Induced Resistance to PD-1/PD-L1 Inhibitors in Lung Cancer

Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice. Bioluminescence imaging, flow cytometry, and immunohistochemistry were employed to determine response to immunotherapy and function of tumor-infiltrating immune cells.