PD-L1

[Scientific Reports] Researchers demonstrated that fibroblast programmed death ligand-1 (PD-L1) may have promoted pulmonary fibrosis through both Smad3 and β-catenin signaling and may represent a novel interventional target for idiopathic pulmonary fibrosis.

[Journal of Experimental & Clinical Cancer Research] Researchers described that RelB participated in the immune evasion of prostate cancer via cis/trans transcriptional upregulation of programmed death receptor ligand (PD-L1).

[Paige] Paige and Flagship Biosciences announced a partnership to provide access to Flagship’s TissueInsight™, an AI-aided diagnostics software that quantifies PD-L1 expression in immunohistochemistry tissue samples, directly through the Paige Platform.

[Gut] Scientists elucidated the nature, regulation and functional relevance of PD-L1+ host cells in HCC.

[Scientific Reports] Utilizing dual-single guide RNAs (sgRNAs) and a homology-directed repair template with the CRISPR/Cas9 gene-editing system is a promising avenue for the treatment of glioblastoma multiforme.

[Oncogene] Scientists created type I interferon (IFN)α-overexpressing MSCs. Upon direct injection into tumors, they found that these cells were powerful in eliminating several types of tumors.