PDAC cells

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.

[Matrix Biology] To identify the integrin adhesion systems that operate in PDAC, investigators analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.

[Journal of Experimental & Clinical Cancer Research] PDAC cells used a distinct and lengthy process of reversible adaptive plasticity centered on the early fast and later slow mitochondrial network dynamics and metabolic adjustment to microenvironmental acidification..

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

[Cell Death & Disease] Researchers observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome.

[Acta Pharmacologica Sinica] Two pan-KRAS inhibitors, BI-2852 and BAY-293, were chosen as chemical probes to investigate their antitumor potency in PDAC.