PI3K

[Applied Materials Today] Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum.

[Cell Death & Disease] Scientists demonstrated that stiffness contributed to mechanosignal transduction in hepatic stellate cells, which promoted hepatocellular carcinoma cells growth and metastasis through secretion of FGF2.

[Bioengineered] Investigators showed that hsa_circ_0030586 was significantly upregulated in prostate cancer (PCa) cells. Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion.

[Bioengineered] Researchers found high TSPAN1 expression in breast cancer tumor samples and cell lines which was confirmed by bioinformation analysis. The ablation of TSPAN1 suppressed the growth, and motility of breast cancer cells and affected the epithelial-mesenchymal transition in breast cancer cells.

[Journal of Biochemistry] Using ectopic plasmid incorporation and siRNA assays, investigators analyzed the circRPPH1-mediated regulation of cell proliferation, migration, and invasion in NSCLC cell lines, using CCK-8, colony forming, scratch wound, and transwell assays, respectively.

[Aging] The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.