PI3K

[Oncogenesis] The authors identified that guanylate-binding protein (GBP)1 and GBP2 interacted with MCL-1, the key prosurvival member of the BCL-2 family, via its BH3 domain. GBPs induced caspase-dependent apoptosis in chronic myeloid leukemia and acute myeloid leukemia cells, where the proapoptotic BCL-2 member, BAK, was an indispensable mediator.

[Chemical Biology & Drug Design] The authors determined the efficacy of pyronaridine in four different NSCLC cell lines and explored its mechanism in H1975.

[Anti-Cancer Agents in Medicinal Chemistry] The authors identified five candidate genes, including ESM1，CXCR4，JAG1，FLT1 and PTK2 and two pathways, including Rap1 signaling pathway and PI3K-Akt signaling pathway in vascular endothelial cells that differentiate into tip cells and stalk cells using bioinformatic analysis.

[Science Signaling] Increasing or decreasing Syk activity by stimulating the γδ T cell receptor (TCRγδ) or inhibiting Syk, respectively, substantially reduced γδ17 cell numbers.

[NPJ Genomic Medicine] Researchers provided a catalog of driver genes in cutaneous squamous cell carcinoma, offering points of therapeutic intervention and insights into the biology of cutaneous squamous cell carcinoma.

[Oncogene] Ligation of Dex and glucocorticoid receptor on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 expression, and then increased the expression of connective tissue growth factor through Nedd4l-Smad2.