Dexamethasone Enhances the Lung Metastasis of Breast Cancer via a PI3K-SGK1-CTGF Pathway

Ligation of Dex and glucocorticoid receptor on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 expression, and then increased the expression of connective tissue growth factor through Nedd4l-Smad2.