Involvement of Multiple Scavenger Receptors in Advanced Glycation End Product-Induced Vessel Tube Formation in Endothelial Cells

Researchers examined the involvement of advanced glycation end (AGE)-related receptors on AGE-induced angiogenesis in endothelial cells.
[Experimental Cell Research]
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Deletion of RAGE Fails to Prevent Hepatosteatosis in Obese Mice Due to Impairment of Other AGEs Receptors and Detoxifying Systems

Scientists analyzed the effect of obesity on advanced glycation endproducts (AGEs) accumulation, AGE-receptors and AGE-detoxification, and whether the absence of RAGE may have improved hepatosteatosis and inflammation, by comparing the liver of lean control, obese and obese RAGE-deficient mice.
[Scientific Reports]
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LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

The effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Knockout RAGE Alleviates Cardiac Fibrosis through Repressing Endothelial-to-Mesenchymal Transition (EndMT) Mediated by Autophagy

Scientists found a decrease in endothelial cells and an increase in cells co-expressing CD31 and α-smooth muscle actin at eight weeks in heart tissue of mice subjected to transverse aortic constriction, which implied EndMT.
[Cell Death & Disease]
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Mesenchymal Stromal Cells Reduce Evidence of Lung Injury in Patients with ARDS

Scientists carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS.
[JCI Insight]
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Verbascoside Inhibits the Epithelial-Mesenchymal Transition of Prostate Cancer Cells through High-Mobility Group Box 1/Receptor for Advanced Glycation End-Products/TGF-β Pathway

Investigators evaluated the effects of purified verbascoside on human prostate cancer and the associated molecular mechanisms.
[Environmental Toxicology]
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Immortalization of Primary Human Alveolar Epithelial Lung Cells Using a Non-Viral Vector to Study Respiratory Bioreactivity In Vitro

To overcome the scarcity of primary human alveolar epithelial cells for lung research, and the limitations of current cell lines to recapitulate the phenotype, functional and molecular characteristics of the healthy human alveolar epithelium, the authors developed a new method to immortalise primary human alveolar epithelial lung cells using a non-viral vector to transfect the telomerase catalytic subunit and the simian virus 40 large-tumor antigen.
[Scientific Reports]
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Bacterial Polyphosphates Interfere with the Innate Host Defense to Infection

Scientists report that mouse survival of peritoneal Escherichia coli sepsis was compromised by long-chain polyphosphates, and improved with bacterial polyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase.
[Nature Communications]
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