RAS

[Gut] Scientists investigated the cellular source for secreted anterior gradient-2 (AGR2) in the tumor microenvironment and underlying mechanisms mediating secreted AGR2’s effects.

[Oncogene] Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.

[Cell Death Discovery] By establishing a mouse model of radiation-induced lung injury and orthotopic lung tumor-bearing mouse model, investigators detected the role of Rac1 inhibition in the protection of RILI and suppression of lung tumor.

[JCI Insight] The authors showed that induced endothelial cell (EC)-specific disruption of Ephb4 in mice resulted in accumulation of collagen IV in the EC endoplasmic reticulum leading to EC apoptotic death and defective developmental, neonatal and pathological angiogenesis.

[Cell Death Discovery] Researchers showed that Nemo-like kinase (NLK) was required for the promotion of SRF/ELK signaling in human and mouse cells.

[Thoracic Cancer] Expression levels of circ_0007385, microRNA-493-3p (miR-493-3p) and Ras-related protein Rab-22A (RAB22A) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in NSCLC tissues and cells.