ROS production

[Circulation Research] Scientists generated transgenic (Tg) rabbits with smooth muscle cell-specific PGC1α overexpression and showed that these rabbits developed significantly less aortic atherosclerosis than their non-Tg littermates after high-cholesterol diet feeding, while total plasma cholesterol levels were similar.

[Acta Pharmacologica Sinica] Expression of an IDH2 mutant mimicking deacetylation in cardiomyocytes promoted myocardial IDH2 activation, quenched mitochondrial reactive oxygen species (ROS), and alleviated post-myocardial infarction (MI) injury, whereas expression of an acetylation mimic in cardiomyocytes inactivated IDH2, exacerbated mitochondrial ROS overload, and aggravated post-MI injury.

[Nature Communications] Investigators discovered that prohibitin (PHB) specifically regulates mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitates GSC radiotherapeutic resistance.

[Nature Communications] The authors discovered that prohibitin specifically regulated mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.

[Free Radical Biology and Medicine] Researchers explored anti-prostate cancer activity in a polyphenol-rich fraction of Bergenia ligulata, a plant used in Indian traditional and folk medicine for its anti-inflammatory and antineoplastic properties.

[Scientific Reports] Investigators identified a new compound that inhibited reactive oxygen species production in isolated mouse cardiomyocytes and improved cardiomyocyte contractility and contraction of whole retrogradely perfused hearts after a global ischemia period.