The authors discovered that prohibitin specifically regulated mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.
[Nature Communications]
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Huang, H., Zhang, S., Li, Y., Liu, Z., Mi, L., Cai, Y., Wang, X., Chen, L., Ran, H., Xiao, D., Li, F., Wu, J., Li, T., Han, Q., Chen, L., Pan, X., Li, H., Li, T., He, K., … Man, J. (2021). Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance. Nature Communications, 12(1), 3720. https://doi.org/10.1038/s41467-021-24108-6 Cite