Notch Pathway Inhibition Mediated by Arsenic Trioxide Depletes Tumor Initiating Cells in Small Cell Lung Cancer

Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway
[Molecular Biology Reports]
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Antineoplastic Effects of Erufosine on Small Cell and Non-Small Cell Lung Cancer Cells through Induction of Apoptosis and Cell Cycle Arrest

The effects of ErPC3 in NSCLC cell line A549 and SCLC cell line DMS 114 in terms of cell viability, induction of apoptosis, cell cycle phase distribution, gene and protein expression levels, and migration capacity were investigated. 25 ┬ÁM ErPC3 exhibited dose-dependent cytotoxicity against in both cancer cells.
[Molecular Biology Reports]
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FK228 Potentiates Topotecan Activity against Small Cell Lung Cancer Cells via Induction of SLFN11

Researchers investigated how schlafen family member 11 (SLFN11) expression regulated the sensitivity of small cell lung cancer to topotecan.
[Acta Pharmacologica Sinica]
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Soluble Guanylate Cyclase Signalling Mediates Etoposide Resistance in Progressing Small Cell Lung Cancer

Scientists exploited six paired pre-treatment and post-chemotherapy circulating tumor cell patient-derived explant models from donors with extensive stage small cell lung cancer to investigate changes at disease progression after chemotherapy.
[Nature Communications]
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TIAM1-RAC1 Promote Small-Cell Lung Cancer Cell Survival through Antagonizing Nur77-Induced BCL2 Conformational Change

Researchers showed that the expression of TIAM1, an activator of the small GTPase RAC1, was associated with a neuroendocrine gene program.
[Cell Reports]
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BeyondSpring Announces First Patient Treated in Phase II Study with Plinabulin Combined with Nivolumab + Ipilimumab in Patients in 3rd Line Recurrent Small-Cell Lung Cancer Patients Who Failed Checkpoint Inhibitors

BeyondSpring announced the first patient has been treated in an investigator-initiated, open-label Phase II study with lead asset plinabulin in combination with nivolumab + ipilimumab in patients with 3rd line recurrent small-cell lung cancer who failed checkpoint inhibitors and platinum-based chemotherapy.
[BeyondSpring, Inc.]
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Lung Neuroendocrine Neoplasms: Recent Progress and Persistent Challenges

The author summarizes key recent developments relevant to the pathologic diagnosis of lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma, and large cell neuroendocrine carcinoma.
[Modern Pathology]
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MAX Mutant Small-Cell Lung Cancers Exhibit Impaired Activities of MGA-Dependent Noncanonical Polycomb Repressive Complex

The MYC axis is disrupted in cancer, predominantly through activation of the MYC family oncogenes but also through inactivation of the MYC partner MAX or of the MAX partner MGA. Researchers demonstrated that MAX-deficient small-cell lung cancer cells have either ASCL1 or NEUROD1 or combined characteristics.
[Proceedings of the National Academy of Sciences of the United States of America]
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Signatures of Plasticity, Metastasis, and Immunosuppression in an Atlas of Human Small Cell Lung Cancer

Scientists sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 small cell lung cancer (SCLC) transcriptomes. They observed greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes.
[Cancer Cell]
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Knockdown of lncRNA HIF1A-AS2 Increases Drug Sensitivity of SCLC Cells in Association with Autophagy

Scientists determined the effect of lncRNA HIF1A-AS2 on autophagy-associated drug resistance in SCLC. The expression of HIF1A-AS2 was silenced by siRNA in doxorubicin-sensitive H69 and doxorubicin-resistant H69AR cells.
[Medical Oncology]
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ASCL1, NKX2-1, and PROX1 Co-Regulate Subtype-Specific Genes in Small Cell Lung Cancer

The authors integrated chromatin landscape and transcriptome analyses of patient-derived small cell lung cancer (SCLC) preclinical models to identify super-enhancers and their associated genes in the ASCL1-, NEUROD1-, and POU2F3-high SCLC subtypes.
[iScience]
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