Cancer-Testis Antigens, Semenogelins 1 and 2, Exhibit Different Anti-Proliferative Effects on Human Lung Adenocarcinoma Cells

Scientists demonstrated that semenogelins 1 and 2 exhibit different patterns of expression and sub-cellular localization in non-small cell lung cancer cell lines.
[Cell Death Discovery]
Shuvalov, O., Kizenko, A., Petukhov, A., Aksenov, N., Fedorova, O., Vorobev, M., Daks, A., & Barlev, N. (2020). Cancer-testis antigens, semenogelins 1 and 2, exhibit different anti-proliferative effects on human lung adenocarcinoma cells. Cell Death Discovery, 6(1), 1–8. https://doi.org/10.1038/s41420-020-00336-5 Cite
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Guanosine Triphosphate Links MYC-Dependent Metabolic and Ribosome Programs in Small Cell Lung Cancer

Investigators demonstrated that primary MYCHigh human small cell lung cancer tumors contain abundant guanosine nucleotides.
[Journal of Clinical Investigation]
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SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

The authors demonstrated the reproducibility and stability of data from multiple sources and validate the small cell lung cancer (SCLC) consensus nomenclature on the basis of expression of master transcription factors NEUROD1, ASCL1, POU2F3, and YAP1.
[Cell Reports]
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ARHGEF19 Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer

Enforced ARHGEF19 expression promotes small cell lung cancer cell proliferation in vitro and its knockdown decreases cell proliferation in vitro and in vivo.
[Biochemical and Biophysical Research Communications]
Wang, Z., Kan, G., Sheng, C., Yao, C., Mao, Y., & Chen, S. (2020). ARHGEF19 regulates MAPK/ERK signaling and promotes the progression of small cell lung cancer. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2020.09.085 Cite
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FGFR1 Is Critical for Rbl2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer

Researchers showed that increased fibroblast growth factor receptor 1 (FGFR1) promoted tumorigenic progression in precancerous neuroendocrine cells and is required for small cell lung cancer development in vivo.
[Cancer Research]
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MYCN Drives Chemoresistance in Small Cell Lung Cancer while USP7 Inhibition Can Restore Chemosensitivity

To study roles for MYCN amplification in small cell lung cancer (SCLC) progression and chemoresistance, we developed a genetically engineered mouse model of MYCN-overexpressing SCLC.
[Genes & Development]
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Distinct Transcriptional Programs of SOX2 in Different Types of Small Cell Lung Cancers

Researchers showed, using next-generation sequencing, that SOX2 expressed in the ASCL1-high small cell lung cancer subtype cell line was dependent on ASCL1, which is a lineage-specific transcriptional factor, and was involved in neuroendocrine differentiation and tumorigenesis.
[Laboratory Investigation]
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Opportunities and Obstacles of Targeted Therapy and Immunotherapy in Small Cell Lung Cancer

The authors review the molecular biology characteristics of small cell lung cancer (SCLC) and discuss the opportunities and obstacles of the current therapy for SCLC patients.
[Journal of Drug Targeting]
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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]
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