Scientists identified non-neuroendocrine SCLC to be vulnerable to ferroptosis through subtype-specific lipidome remodeling.
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Bebber, C. M., Thomas, E. S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M. N., Stüker, L., de Pádua Alves, C., Khonsari, A., Dammert, M. A., Parmaksiz, F., Tumbrink, H. L., Beleggia, F., Sos, M. L., Riemer, J., George, J., Brodesser, S., Thomas, R. K., … von Karstedt, S. (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications, 12(1), 2048. https://doi.org/10.1038/s41467-021-22336-4 Cite
The authors discuss the experimental models of lung cancer and metastasis, mechanisms in SCLC transfer and the challenges about clinical management of lung cancer.
[Biomedicine & Pharmacotherapy]
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Researchers uncovered that FK228 sensitized human radioresistant SCLC cells to radiation mainly through induction of chromatin decondensation and suppression of DNA damage signaling and repair.
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Investigators clarified the role of neuron-specific enolase (NSE) in the progression of SCLC and found that NSE expression was positively correlated with distant metastasis.
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Using tumor expression data and non-negative matrix factorization, scientists identified four small cell lung cancer (SCLC) subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature.
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Researchers investigated the potential effect of combining Rovalpituzumab tesirine and CBL0137 in small cell lung cancer to eradicate tumor-initiating cells more effectively.
[British Journal of Cancer]
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Ipsen announced the FDA has granted the company Fast Track designation for irinotecan liposome injection in study patients with SCLC who progressed following a first-line platinum-based regimen, reflecting the unmet medical need.
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AMG 757 efficacy was evaluated in small cell lung cancer (SCLC) cell lines and in orthotopic and patient-derived xenograft mouse SCLC models. Following AMG 757 administration, changes in tumor volume, pharmacodynamic changes in tumor-infiltrating T cells (TILs), and the spatial relationship between the appearance of TILs and tumor histology were examined. Tolerability was assessed in nonhuman primates.
[Clinical Cancer Research]
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Researchers investigated whether bortezomib or carfilzomib combined with obatoclax, an antagonist for MCL-1 and a pan-BCL family inhibitor, could cause synergistic growth inhibition of small cell lung cancer cells.
[Acta Pharmacologica Sinica]
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Scientists demonstrated that semenogelins 1 and 2 exhibit different patterns of expression and sub-cellular localization in non-small cell lung cancer cell lines.
[Cell Death Discovery]
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Investigators demonstrated that primary MYCHigh human small cell lung cancer tumors contain abundant guanosine nucleotides.
[Journal of Clinical Investigation]
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