MAX Mutant Small-Cell Lung Cancers Exhibit Impaired Activities of MGA-Dependent Noncanonical Polycomb Repressive Complex

The MYC axis is disrupted in cancer, predominantly through activation of the MYC family oncogenes but also through inactivation of the MYC partner MAX or of the MAX partner MGA. Researchers demonstrated that MAX-deficient small-cell lung cancer cells have either ASCL1 or NEUROD1 or combined characteristics.
[Proceedings of the National Academy of Sciences of the United States of America]
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Signatures of Plasticity, Metastasis, and Immunosuppression in an Atlas of Human Small Cell Lung Cancer

Scientists sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 small cell lung cancer (SCLC) transcriptomes. The authors observe greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes.
[Cancer Cell]
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Knockdown of lncRNA HIF1A-AS2 Increases Drug Sensitivity of SCLC Cells in Association with Autophagy

Scientists determined the effect of lncRNA HIF1A-AS2 on autophagy-associated drug resistance in SCLC. The expression of HIF1A-AS2 was silenced by siRNA in doxorubicin-sensitive H69 and doxorubicin-resistant H69AR cells.
[Medical Oncology]
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ASCL1, NKX2-1, and PROX1 Co-Regulate Subtype-Specific Genes in Small Cell Lung Cancer

The authors integrated chromatin landscape and transcriptome analyses of patient-derived small cell lung cancer (SCLC) preclinical models to identify super-enhancers and their associated genes in the ASCL1-, NEUROD1-, and POU2F3-high SCLC subtypes.
[iScience]
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Recent Developments in the Treatment of Small Cell Lung Cancer

Scientists describe the progress that has been made in systemic treatment by repurposing existing drugs and the addition of targeted treatment.
[European Respiratory Review]
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Single-Cell microRNA Sequencing Method Comparison and Application to Cell Lines and Circulating Lung Tumor Cells

Scientists evaluated 19 protocols for single cell small RNA sequencing on MCF7 cells spiked with 1 pg of 1,006 miRNAs.
[Nature Communications]
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Discovery of a Novel CDK7 Inhibitor YPN-005 in Small Cell Lung Cancer

Investigators developed a potent inhibitor of cyclin-dependent kinase 7 (CDK7), designated YPN-005, and determined whether it showed any anticancer effects in small cell lung cancer (SCLC), cells, cisplatin or etoposide-resistant cells, or organoids derived from SCLC patients.
[European Journal of Pharmacology]
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Small Cell Lung Cancer Stem Cells Display Mesenchymal Properties and Exploit Immune Checkpoint Pathways in Activated Cytotoxic T Lymphocytes

To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.
[Cancer Immunology, Immunotherapy]
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De Novo Deoxyribonucleotide Biosynthesis Regulates Cell Growth and Tumor Progression in Small-Cell Lung Carcinoma

Scientists established siRNA-transfected small-cell lung carcinoma cell lines to investigate the anticancer effect of silencing ribonucleotide reductase large subunit gene expression.
[Scientific Reports]
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Multi-Omic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation

Scientists identified genomic contexts in which neuroendocrine transformation was favored, including frequent loss of the 3p chromosome arm.
[Cancer Discovery]
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Notch Signaling and Efficacy of PD-1/PD-L1 Blockade in Relapsed Small Cell Lung Cancer

To identify predictors of clinical benefit to immune checkpoint blockade, investigators performed immunogenomic profiling of tumor samples from patients with relapsed small cell lung cancer.
[Nature Communications]
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