Ferroptosis Response Segregates Small Cell Lung Cancer (SCLC) Neuroendocrine Subtypes

Scientists identified non-neuroendocrine SCLC to be vulnerable to ferroptosis through subtype-specific lipidome remodeling.
[Nature Communications]
Bebber, C. M., Thomas, E. S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M. N., Stüker, L., de Pádua Alves, C., Khonsari, A., Dammert, M. A., Parmaksiz, F., Tumbrink, H. L., Beleggia, F., Sos, M. L., Riemer, J., George, J., Brodesser, S., Thomas, R. K., … von Karstedt, S. (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications, 12(1), 2048. https://doi.org/10.1038/s41467-021-22336-4 Cite
Full Article
Bookmark

No account yet? Register

0
Share

The Metastasizing Mechanisms of Lung Cancer: Recent Advances and Therapeutic Challenges

The authors discuss the experimental models of lung cancer and metastasis, mechanisms in SCLC transfer and the challenges about clinical management of lung cancer.
[Biomedicine & Pharmacotherapy]
Full Article
Bookmark

No account yet? Register

0
Share

FK228 Sensitizes Radioresistant Small Cell Lung Cancer Cells to Radiation

Researchers uncovered that FK228 sensitized human radioresistant SCLC cells to radiation mainly through induction of chromatin decondensation and suppression of DNA damage signaling and repair.
[Clinical Epigenetics]
Full Article
Bookmark

No account yet? Register

0
Share

Neuron Specific Enolase Promotes Tumor Metastasis by Activating the Wnt/β-Catenin Pathway in Small Cell Lung Cancer

Investigators clarified the role of neuron-specific enolase (NSE) in the progression of SCLC and found that NSE expression was positively correlated with distant metastasis.
[Translational Oncology]
Full Article
Bookmark

No account yet? Register

0
Share

Patterns of Transcription Factor Programs and Immune Pathway Activation Define Four Major Subtypes of SCLC with Distinct Therapeutic Vulnerabilities

Using tumor expression data and non-negative matrix factorization, scientists identified four small cell lung cancer (SCLC) subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature.
[Cancer Cell]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

CBL0137 Increases the Targeting Efficacy of Rovalpituzumab Tesirine against Tumor-Initiating Cells in Small Cell Lung Cancer

Researchers investigated the potential effect of combining Rovalpituzumab tesirine and CBL0137 in small cell lung cancer to eradicate tumor-initiating cells more effectively.
[British Journal of Cancer]
Abstract
Bookmark

No account yet? Register

0
Share

Ipsen Receives FDA Fast Track Designation for Investigational Irinotecan Liposome Injection (ONIVYDE®) as a Second-Line Monotherapy Treatment for Small Cell Lung Cancer (SCLC)

Ipsen announced the FDA has granted the company Fast Track designation for irinotecan liposome injection in study patients with SCLC who progressed following a first-line platinum-based regimen, reflecting the unmet medical need.
[Ipsen]
Press Release
Bookmark

No account yet? Register

0
Share

AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer

AMG 757 efficacy was evaluated in small cell lung cancer (SCLC) cell lines and in orthotopic and patient-derived xenograft mouse SCLC models. Following AMG 757 administration, changes in tumor volume, pharmacodynamic changes in tumor-infiltrating T cells (TILs), and the spatial relationship between the appearance of TILs and tumor histology were examined. Tolerability was assessed in nonhuman primates.
[Clinical Cancer Research]
Abstract
Bookmark

No account yet? Register

0
Share

Combinations of Proteasome Inhibitors with Obatoclax Are Effective for Small Cell Lung Cancer

Researchers investigated whether bortezomib or carfilzomib combined with obatoclax, an antagonist for MCL-1 and a pan-BCL family inhibitor, could cause synergistic growth inhibition of small cell lung cancer cells.
[Acta Pharmacologica Sinica]
Abstract
Bookmark

No account yet? Register

0
Share

Cancer-Testis Antigens, Semenogelins 1 and 2, Exhibit Different Anti-Proliferative Effects on Human Lung Adenocarcinoma Cells

Scientists demonstrated that semenogelins 1 and 2 exhibit different patterns of expression and sub-cellular localization in non-small cell lung cancer cell lines.
[Cell Death Discovery]
Full Article
Bookmark

No account yet? Register

0
Share

Guanosine Triphosphate Links MYC-Dependent Metabolic and Ribosome Programs in Small Cell Lung Cancer

Investigators demonstrated that primary MYCHigh human small cell lung cancer tumors contain abundant guanosine nucleotides.
[Journal of Clinical Investigation]
AbstractFull Article
Bookmark

No account yet? Register

0
Share
Share