Promoters of ASCL1- and NEUROD1-Dependent Genes Are Specific Targets of Lurbinectedin in SCLC Cells

Investigators focused on the neuroendocrine SCLC subtypes, SCLC-A and SCLC-N, whose transcription addiction was driven by ASCL1 and NEUROD1 transcription factors which targeted E-box motifs to activate up to 40% of total genes.